Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition

Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition

Human aldo-keto reductase 1B10 (AKR1B10) is overexpressed in many cancer types and is involved in chemoresistance. This makes AKR1B10 to be an interesting drug target and thus many enzyme inhibitors have been investigated. High-resolution crystallographic structures of AKR1B10 with various reversibl...

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Bibliographic Details
Main Authors: Francesc Xavier Ruiz, Xavier Parés, Jaume Farrés
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Metabolites
Subjects:
aldo-keto reductase
aldose reductase
cancer
enzyme inhibitor
structure-based drug design
Online Access:https://www.mdpi.com/2218-1989/11/12/865

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