Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis
The role of regulatory cis-elements in carcinogenesis and metastasis in esophageal squamous cell carcinoma remains crucial. Here the authors investigate H3K27ac-marked active enhancer profiles and transcriptomes in different types of esophageal tissues and identify oncogenic events and potential the...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24813-2 |
| _version_ | 1818342743995318272 |
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| author | Bo Ye Dandan Fan Weiwei Xiong Min Li Jian Yuan Qi Jiang Yuting Zhao Jianxiang Lin Jie Liu Yilv Lv Xiongjun Wang Zhigang Li Jianzhong Su Yunbo Qiao |
| author_facet | Bo Ye Dandan Fan Weiwei Xiong Min Li Jian Yuan Qi Jiang Yuting Zhao Jianxiang Lin Jie Liu Yilv Lv Xiongjun Wang Zhigang Li Jianzhong Su Yunbo Qiao |
| author_sort | Bo Ye |
| collection | DOAJ |
| description | The role of regulatory cis-elements in carcinogenesis and metastasis in esophageal squamous cell carcinoma remains crucial. Here the authors investigate H3K27ac-marked active enhancer profiles and transcriptomes in different types of esophageal tissues and identify oncogenic events and potential therapeutic targets. |
| first_indexed | 2024-12-13T16:19:33Z |
| format | Article |
| id | doaj.art-1f28e58954f6472a90d785799d564ad2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:19:33Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1f28e58954f6472a90d785799d564ad22022-12-21T23:38:45ZengNature PortfolioNature Communications2041-17232021-07-0112111610.1038/s41467-021-24813-2Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasisBo Ye0Dandan Fan1Weiwei Xiong2Min Li3Jian Yuan4Qi Jiang5Yuting Zhao6Jianxiang Lin7Jie Liu8Yilv Lv9Xiongjun Wang10Zhigang Li11Jianzhong Su12Yunbo Qiao13Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong UniversitySchool of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityPrecise Genome Engineering Center, School of Life Sciences, Guangzhou UniversityPrecise Genome Engineering Center, School of Life Sciences, Guangzhou UniversitySchool of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversitySchool of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityPrecise Genome Engineering Center, School of Life Sciences, Guangzhou UniversityPrecise Genome Engineering Center, School of Life Sciences, Guangzhou UniversityPrecise Genome Engineering Center, School of Life Sciences, Guangzhou UniversityDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong UniversityPrecise Genome Engineering Center, School of Life Sciences, Guangzhou UniversityDepartment of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong UniversitySchool of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical UniversityPrecise Genome Engineering Center, School of Life Sciences, Guangzhou UniversityThe role of regulatory cis-elements in carcinogenesis and metastasis in esophageal squamous cell carcinoma remains crucial. Here the authors investigate H3K27ac-marked active enhancer profiles and transcriptomes in different types of esophageal tissues and identify oncogenic events and potential therapeutic targets.https://doi.org/10.1038/s41467-021-24813-2 |
| spellingShingle | Bo Ye Dandan Fan Weiwei Xiong Min Li Jian Yuan Qi Jiang Yuting Zhao Jianxiang Lin Jie Liu Yilv Lv Xiongjun Wang Zhigang Li Jianzhong Su Yunbo Qiao Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis Nature Communications |
| title | Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis |
| title_full | Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis |
| title_fullStr | Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis |
| title_full_unstemmed | Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis |
| title_short | Oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis |
| title_sort | oncogenic enhancers drive esophageal squamous cell carcinogenesis and metastasis |
| url | https://doi.org/10.1038/s41467-021-24813-2 |
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