Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice

Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice

Sirtuin 1 (Sirt1) is an essential modulator of cellular metabolism and has pleiotropic effects. It was recently reported that Sirt1 overexpression in kidney tubule ameliorates cisplatin-induced acute kidney injury (AKI). However, whether pharmacological activation of Sirt1 also has a beneficial effe...

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Bibliographic Details
Main Authors: Jung-Yeon Kim, Jungmin Jo, Kiryeong Kim, Hyun-Jin An, Mi-Gyeong Gwon, Hyemin Gu, Hyun-Ju Kim, A Young Yang, Sung-Woo Kim, Eon Ju Jeon, Jae-Hyung Park, Jaechan Leem, Kwan-Kyu Park
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Antioxidants
Subjects:
sirtuin 1
SRT1720
cisplatin
acute kidney injury
apoptosis
oxidative stress
inflammation
Online Access:https://www.mdpi.com/2076-3921/8/8/322

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