Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation

Osteoblast-secreted collagen upregulates paracrine Sonic hedgehog signaling by prostate cancer cells and enhances osteoblast differentiation

<p>Abstract</p> <p>Background</p> <p>Induction of osteoblast differentiation by paracrine Sonic hedgehog (Shh) signaling may be a mechanism through which Shh-expressing prostate cancer cells initiate changes in the bone microenvironment and promote metastases. A hallmar...

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Bibliographic Details
Main Authors: Zunich Samantha M, Valdovinos Maria, Douglas Taneka, Walterhouse David, Iannaccone Philip, Lamm Marilyn LG
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Molecular Cancer
Subjects:
Prostate cancer
Bone metastasis
Hedgehog
Collagen
Extracellular matrix
Osteoblast differentiation
Online Access:http://www.molecular-cancer.com/content/11/1/30

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