Population Structure of East African Relapsing Fever Borrelia spp.
Differentiation of endemic East African tick-borne relapsing fever Borrelia duttonii spirochetes from epidemic louse-borne relapsing fever (LBRF) B. recurrentis spirochetes into different species has been questioned. We assessed a noncoding intragenic spacer (IGS) region to compare genotypes found i...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2010-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/16/7/09-1085_article |
| _version_ | 1818133630221811712 |
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| author | Sally J. Cutler E. Margarita Bonilla Rajbir J. Singh |
| author_facet | Sally J. Cutler E. Margarita Bonilla Rajbir J. Singh |
| author_sort | Sally J. Cutler |
| collection | DOAJ |
| description | Differentiation of endemic East African tick-borne relapsing fever Borrelia duttonii spirochetes from epidemic louse-borne relapsing fever (LBRF) B. recurrentis spirochetes into different species has been questioned. We assessed a noncoding intragenic spacer (IGS) region to compare genotypes found in clinical samples from relapsing fever patients. Although IGS typing was highly discriminatory and resolved 4 East African tick-borne relapsing fever groups from a disease-endemic region in Tanzania, 2 IGS clades were found among LBRF patients in Ethiopia. The 2 IGS sequence types for B. recurrentis overlapped with 2 of the 4 groups found among B. duttonii. All cultivable isolates of B. duttonii fell into a single IGS cluster, which suggests their analysis might introduce selective bias. We provide further support that B. recurrentis is a subset of B. duttonii and represents an ecotype rather than a species. These observations have disease control implications and suggest LBRF Borrelia spp. could reemerge from its tick-borne reservoirs where vectors coexist. |
| first_indexed | 2024-12-11T08:55:46Z |
| format | Article |
| id | doaj.art-1f2f2f5c3c0445cc92bc8264d67a93b4 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T08:55:46Z |
| publishDate | 2010-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-1f2f2f5c3c0445cc92bc8264d67a93b42022-12-22T01:13:54ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592010-07-011671076108010.3201/eid1607.091085Population Structure of East African Relapsing Fever Borrelia spp.Sally J. CutlerE. Margarita BonillaRajbir J. SinghDifferentiation of endemic East African tick-borne relapsing fever Borrelia duttonii spirochetes from epidemic louse-borne relapsing fever (LBRF) B. recurrentis spirochetes into different species has been questioned. We assessed a noncoding intragenic spacer (IGS) region to compare genotypes found in clinical samples from relapsing fever patients. Although IGS typing was highly discriminatory and resolved 4 East African tick-borne relapsing fever groups from a disease-endemic region in Tanzania, 2 IGS clades were found among LBRF patients in Ethiopia. The 2 IGS sequence types for B. recurrentis overlapped with 2 of the 4 groups found among B. duttonii. All cultivable isolates of B. duttonii fell into a single IGS cluster, which suggests their analysis might introduce selective bias. We provide further support that B. recurrentis is a subset of B. duttonii and represents an ecotype rather than a species. These observations have disease control implications and suggest LBRF Borrelia spp. could reemerge from its tick-borne reservoirs where vectors coexist.https://wwwnc.cdc.gov/eid/article/16/7/09-1085_articleRelapsing feverBorrelialouse-borne relapsing fevertick-borne relapsing fevervector-borne infectionsEthiopia |
| spellingShingle | Sally J. Cutler E. Margarita Bonilla Rajbir J. Singh Population Structure of East African Relapsing Fever Borrelia spp. Emerging Infectious Diseases Relapsing fever Borrelia louse-borne relapsing fever tick-borne relapsing fever vector-borne infections Ethiopia |
| title | Population Structure of East African Relapsing Fever Borrelia spp. |
| title_full | Population Structure of East African Relapsing Fever Borrelia spp. |
| title_fullStr | Population Structure of East African Relapsing Fever Borrelia spp. |
| title_full_unstemmed | Population Structure of East African Relapsing Fever Borrelia spp. |
| title_short | Population Structure of East African Relapsing Fever Borrelia spp. |
| title_sort | population structure of east african relapsing fever borrelia spp |
| topic | Relapsing fever Borrelia louse-borne relapsing fever tick-borne relapsing fever vector-borne infections Ethiopia |
| url | https://wwwnc.cdc.gov/eid/article/16/7/09-1085_article |
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