Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in human
Under the background of the severe human health and world economic burden caused by COVID-19, the attenuation of vaccine protection efficacy, and the prevalence and immune escape of emerging variants of concern (VOCs), the third dose of booster immunization has been put on the agenda. Systems biolog...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1027180/full |
| _version_ | 1797990772148011008 |
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| author | Yuwei Zhang Mingxiao Yao Xingyu Guo Shanshan Han Shu Zhang Jinzhong Zhang Xiangkun Jiang Jianxing Wang Ming Fang Shuang Wang Bo Pang Xiaolin Liu Zengqiang Kou Xiaolin Jiang Xiaolin Jiang |
| author_facet | Yuwei Zhang Mingxiao Yao Xingyu Guo Shanshan Han Shu Zhang Jinzhong Zhang Xiangkun Jiang Jianxing Wang Ming Fang Shuang Wang Bo Pang Xiaolin Liu Zengqiang Kou Xiaolin Jiang Xiaolin Jiang |
| author_sort | Yuwei Zhang |
| collection | DOAJ |
| description | Under the background of the severe human health and world economic burden caused by COVID-19, the attenuation of vaccine protection efficacy, and the prevalence and immune escape of emerging variants of concern (VOCs), the third dose of booster immunization has been put on the agenda. Systems biology approaches can help us gain new perspectives on the characterization of immune responses and the identification of factors underlying vaccine-induced immune efficacy. We analyzed the antibody signature and transcriptional responses of participants vaccinated with COVID-19 inactivated vaccine and protein subunit vaccine as a third booster dose. The results from the antibody indicated that the third booster dose was effective, and that heterologous vaccination with the protein subunit vaccine as a booster dose induced stronger humoral immune responses than the homologous vaccination with inactivated vaccine, and might be more effective against VOCs. In transcriptomic analysis, protein subunit vaccine induced more differentially expressed genes that were significantly associated with many important innate immune pathways. Both the homologous and heterologous boosters could increase the effectiveness against COVID-19, and compared with the inactivated vaccine, the protein subunit vaccine, mediated a stronger humoral immune response and had a more significant correlation with the innate immune function module, which provided certain data support for the third booster immunization strategy. |
| first_indexed | 2024-04-11T08:40:40Z |
| format | Article |
| id | doaj.art-1f2f7c3fa36047898b6fe26b7c231eee |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T08:40:40Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1f2f7c3fa36047898b6fe26b7c231eee2022-12-22T04:34:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-10-011310.3389/fimmu.2022.10271801027180Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in humanYuwei Zhang0Mingxiao Yao1Xingyu Guo2Shanshan Han3Shu Zhang4Jinzhong Zhang5Xiangkun Jiang6Jianxing Wang7Ming Fang8Shuang Wang9Bo Pang10Xiaolin Liu11Zengqiang Kou12Xiaolin Jiang13Xiaolin Jiang14Infectious Disease Prevention and Control Section, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, ChinaInfectious Disease Prevention and Control Section, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, ChinaSchool of Public Health and Health Management, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSchool of Public Health and Health Management, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaInfectious Disease Prevention and Control Section, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, ChinaInstitute of Immunization and Prevention, Liaocheng Center for Disease Control and Prevention, Liaocheng, Shandong, ChinaInstitute of Immunization and Prevention, Liaocheng Center for Disease Control and Prevention, Liaocheng, Shandong, ChinaInfectious Disease Prevention and Control Section, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, ChinaInfectious Disease Prevention and Control Section, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, ChinaInfectious Disease Prevention and Control Section, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, ChinaInfectious Disease Prevention and Control Section, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, ChinaInfectious Disease Prevention and Control Section, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, ChinaInfectious Disease Prevention and Control Section, Shandong Provincial Center for Disease Control and Prevention, Jinan, Shandong, ChinaSchool of Public Health and Health Management, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaShandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Provincial Center for Disease Control and Prevention, Jinan, ChinaUnder the background of the severe human health and world economic burden caused by COVID-19, the attenuation of vaccine protection efficacy, and the prevalence and immune escape of emerging variants of concern (VOCs), the third dose of booster immunization has been put on the agenda. Systems biology approaches can help us gain new perspectives on the characterization of immune responses and the identification of factors underlying vaccine-induced immune efficacy. We analyzed the antibody signature and transcriptional responses of participants vaccinated with COVID-19 inactivated vaccine and protein subunit vaccine as a third booster dose. The results from the antibody indicated that the third booster dose was effective, and that heterologous vaccination with the protein subunit vaccine as a booster dose induced stronger humoral immune responses than the homologous vaccination with inactivated vaccine, and might be more effective against VOCs. In transcriptomic analysis, protein subunit vaccine induced more differentially expressed genes that were significantly associated with many important innate immune pathways. Both the homologous and heterologous boosters could increase the effectiveness against COVID-19, and compared with the inactivated vaccine, the protein subunit vaccine, mediated a stronger humoral immune response and had a more significant correlation with the innate immune function module, which provided certain data support for the third booster immunization strategy.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1027180/fullCOVID-19third booster vaccinevariants of concernhumoral immunitytranscriptome analysis |
| spellingShingle | Yuwei Zhang Mingxiao Yao Xingyu Guo Shanshan Han Shu Zhang Jinzhong Zhang Xiangkun Jiang Jianxing Wang Ming Fang Shuang Wang Bo Pang Xiaolin Liu Zengqiang Kou Xiaolin Jiang Xiaolin Jiang Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in human Frontiers in Immunology COVID-19 third booster vaccine variants of concern humoral immunity transcriptome analysis |
| title | Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in human |
| title_full | Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in human |
| title_fullStr | Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in human |
| title_full_unstemmed | Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in human |
| title_short | Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in human |
| title_sort | humoral immunity and transcriptome differences of covid 19 inactivated vacciane and protein subunit vaccine as third booster dose in human |
| topic | COVID-19 third booster vaccine variants of concern humoral immunity transcriptome analysis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1027180/full |
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