Advanced approaches of the use of circRNAs as a replacement for cancer therapy
Cancer is a broad name for a group of diseases in which abnormal cells grow out of control and are characterized by their complexity and recurrence. Although there has been progress in cancer therapy with the entry of precision medicine and immunotherapy, cancer incidence rates have increased global...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-09-01
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| Series: | Non-coding RNA Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024000805 |
| _version_ | 1797226607809658880 |
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| author | Goran Sedeeq Hama Faraj Bashdar Mahmud Hussen Snur Rasool Abdullah Mohammed Fatih Rasul Yasaman Hajiesmaeili Aria Baniahmad Mohammad Taheri |
| author_facet | Goran Sedeeq Hama Faraj Bashdar Mahmud Hussen Snur Rasool Abdullah Mohammed Fatih Rasul Yasaman Hajiesmaeili Aria Baniahmad Mohammad Taheri |
| author_sort | Goran Sedeeq Hama Faraj |
| collection | DOAJ |
| description | Cancer is a broad name for a group of diseases in which abnormal cells grow out of control and are characterized by their complexity and recurrence. Although there has been progress in cancer therapy with the entry of precision medicine and immunotherapy, cancer incidence rates have increased globally. Non-coding RNAs in the form of circular RNAs (circRNAs) play crucial roles in the pathogenesis, clinical diagnosis, and therapy of different diseases, including cancer. According to recent studies, circRNAs appear to serve as accurate indicators and therapeutic targets for cancer treatment. However, circRNAs are promising candidates for cutting-edge cancer therapy because of their distinctive circular structure, stability, and wide range of capabilities; many challenges persist that decrease the applications of circRNA-based cancer therapeutics. Here, we explore the roles of circRNAs as a replacement for cancer therapy, highlight the main challenges facing circRNA-based cancer therapies, and discuss the key strategies to overcome these challenges to improve advanced innovative therapies based on circRNAs with long-term health effects. |
| first_indexed | 2024-04-24T14:27:36Z |
| format | Article |
| id | doaj.art-1f2f8180d3d8483ebf5b3eab66fa4c26 |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T14:27:36Z |
| publishDate | 2024-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-1f2f8180d3d8483ebf5b3eab66fa4c262024-04-03T04:27:09ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-09-0193811830Advanced approaches of the use of circRNAs as a replacement for cancer therapyGoran Sedeeq Hama Faraj0Bashdar Mahmud Hussen1Snur Rasool Abdullah2Mohammed Fatih Rasul3Yasaman Hajiesmaeili4Aria Baniahmad5Mohammad Taheri6Department of Medical Laboratory Science, Komar University of Science and Technology, Sulaymaniyah, 46001, IraqDepartment of Biomedical Sciences, College of Science, Cihan University-Erbil, Erbil, Kurdistan Region, 44001, Iraq; Department of Clinical Analysis, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, 44001, Iraq; Corresponding author. Department of Biomedical Sciences, College of Science, Cihan University-Erbil, Erbil, Kurdistan Region, 44001, IraqMedical Laboratory Science, Lebanese French University, Erbil, Kurdistan Region, 44001, IraqDepartment of Pharmaceutical Basic Science, Faculty of Pharmacy, Tishk International University, Erbil, Kurdistan Region, IraqFaculty of Health, York University, Toronto, ON, CanadaInstitute of Human Genetics, Jena University Hospital, Jena, Germany; Corresponding author.Institute of Human Genetics, Jena University Hospital, Jena, Germany; Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Corresponding author. Institute of Human Genetics, Jena University Hospital, Jena, GermanyCancer is a broad name for a group of diseases in which abnormal cells grow out of control and are characterized by their complexity and recurrence. Although there has been progress in cancer therapy with the entry of precision medicine and immunotherapy, cancer incidence rates have increased globally. Non-coding RNAs in the form of circular RNAs (circRNAs) play crucial roles in the pathogenesis, clinical diagnosis, and therapy of different diseases, including cancer. According to recent studies, circRNAs appear to serve as accurate indicators and therapeutic targets for cancer treatment. However, circRNAs are promising candidates for cutting-edge cancer therapy because of their distinctive circular structure, stability, and wide range of capabilities; many challenges persist that decrease the applications of circRNA-based cancer therapeutics. Here, we explore the roles of circRNAs as a replacement for cancer therapy, highlight the main challenges facing circRNA-based cancer therapies, and discuss the key strategies to overcome these challenges to improve advanced innovative therapies based on circRNAs with long-term health effects.http://www.sciencedirect.com/science/article/pii/S2468054024000805CancerCancer therapyCircRNAsChallengesStrategies |
| spellingShingle | Goran Sedeeq Hama Faraj Bashdar Mahmud Hussen Snur Rasool Abdullah Mohammed Fatih Rasul Yasaman Hajiesmaeili Aria Baniahmad Mohammad Taheri Advanced approaches of the use of circRNAs as a replacement for cancer therapy Non-coding RNA Research Cancer Cancer therapy CircRNAs Challenges Strategies |
| title | Advanced approaches of the use of circRNAs as a replacement for cancer therapy |
| title_full | Advanced approaches of the use of circRNAs as a replacement for cancer therapy |
| title_fullStr | Advanced approaches of the use of circRNAs as a replacement for cancer therapy |
| title_full_unstemmed | Advanced approaches of the use of circRNAs as a replacement for cancer therapy |
| title_short | Advanced approaches of the use of circRNAs as a replacement for cancer therapy |
| title_sort | advanced approaches of the use of circrnas as a replacement for cancer therapy |
| topic | Cancer Cancer therapy CircRNAs Challenges Strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024000805 |
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