3D printed scaffolds: Challenges toward developing relevant cellular in vitro models
Three-dimensional (3D) cell culture technology has rapidly emerged, as a result of the increasing demand for improved in vitro systems that better resemble human physiology. Promising microphysiological systems have been fabricated by combining complex 3D culture with 3D-printing technologies. These...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Biomaterials and Biosystems |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266653442200006X |
| _version_ | 1818245095764262912 |
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| author | Beatriz Molina-Martínez Luis M. Liz-Marzán |
| author_facet | Beatriz Molina-Martínez Luis M. Liz-Marzán |
| author_sort | Beatriz Molina-Martínez |
| collection | DOAJ |
| description | Three-dimensional (3D) cell culture technology has rapidly emerged, as a result of the increasing demand for improved in vitro systems that better resemble human physiology. Promising microphysiological systems have been fabricated by combining complex 3D culture with 3D-printing technologies. These models overperform existing in vitro systems regarding potential for biofabrication and predictive power. However, most systems under development do not ultimately find a long-term application. We provide herein an overview of the challenges to be considered when developing 3D in vitro systems by means of printed scaffolds, as well as some of the limitations of existing models. |
| first_indexed | 2024-12-12T14:27:28Z |
| format | Article |
| id | doaj.art-1f31f9e3de7a425f9f63a7e0826a6bce |
| institution | Directory Open Access Journal |
| issn | 2666-5344 |
| language | English |
| last_indexed | 2024-12-12T14:27:28Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomaterials and Biosystems |
| spelling | doaj.art-1f31f9e3de7a425f9f63a7e0826a6bce2022-12-22T00:21:38ZengElsevierBiomaterials and Biosystems2666-53442022-06-0161000443D printed scaffolds: Challenges toward developing relevant cellular in vitro modelsBeatriz Molina-Martínez0Luis M. Liz-Marzán1CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), 20014 Donostia-San Sebastián, Spain; Corresponding authors.CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), 20014 Donostia-San Sebastián, Spain; Biomedical Research Networking Center in Bioengineering, Biomaterials, and Nanomedicine (CIBER- BBN), 20014 Donostia-San Sebastián, Spain; Ikerbasque, Basque Foundation for Science, 48009 Bilbao, Spain; Corresponding authors.Three-dimensional (3D) cell culture technology has rapidly emerged, as a result of the increasing demand for improved in vitro systems that better resemble human physiology. Promising microphysiological systems have been fabricated by combining complex 3D culture with 3D-printing technologies. These models overperform existing in vitro systems regarding potential for biofabrication and predictive power. However, most systems under development do not ultimately find a long-term application. We provide herein an overview of the challenges to be considered when developing 3D in vitro systems by means of printed scaffolds, as well as some of the limitations of existing models.http://www.sciencedirect.com/science/article/pii/S266653442200006X3D PrintingCell cultureScaffolds |
| spellingShingle | Beatriz Molina-Martínez Luis M. Liz-Marzán 3D printed scaffolds: Challenges toward developing relevant cellular in vitro models Biomaterials and Biosystems 3D Printing Cell culture Scaffolds |
| title | 3D printed scaffolds: Challenges toward developing relevant cellular in vitro models |
| title_full | 3D printed scaffolds: Challenges toward developing relevant cellular in vitro models |
| title_fullStr | 3D printed scaffolds: Challenges toward developing relevant cellular in vitro models |
| title_full_unstemmed | 3D printed scaffolds: Challenges toward developing relevant cellular in vitro models |
| title_short | 3D printed scaffolds: Challenges toward developing relevant cellular in vitro models |
| title_sort | 3d printed scaffolds challenges toward developing relevant cellular in vitro models |
| topic | 3D Printing Cell culture Scaffolds |
| url | http://www.sciencedirect.com/science/article/pii/S266653442200006X |
| work_keys_str_mv | AT beatrizmolinamartinez 3dprintedscaffoldschallengestowarddevelopingrelevantcellularinvitromodels AT luismlizmarzan 3dprintedscaffoldschallengestowarddevelopingrelevantcellularinvitromodels |