Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease
Vogt-Koyanagi-Harada (VKH) disease is an auto-immune inflammatory disease of choroidal origin. During the acute stage, optical coherence tomography (OCT), however, may not be able to assess the entire choroid. The aims of the paper were to evaluate the role of retinal pigment epithelium (RPE) as a b...
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| author | Ninan Jacob Mudit Tyagi Jay Chhablani Raja Narayanan Anup Kelgaonkar Mukesh Jain Sumit Randhir Singh Niroj Kumar Sahoo |
| author_facet | Ninan Jacob Mudit Tyagi Jay Chhablani Raja Narayanan Anup Kelgaonkar Mukesh Jain Sumit Randhir Singh Niroj Kumar Sahoo |
| author_sort | Ninan Jacob |
| collection | DOAJ |
| description | Vogt-Koyanagi-Harada (VKH) disease is an auto-immune inflammatory disease of choroidal origin. During the acute stage, optical coherence tomography (OCT), however, may not be able to assess the entire choroid. The aims of the paper were to evaluate the role of retinal pigment epithelium (RPE) as a biomarker of inflammation in acute VKH. This was a retrospective observational study done in 55 eyes of 29 patients with acute VKH. RPE thickness, total choroidal thickness, and RPE reflectivity before and after resolution were analyzed using image J software. Correlations between several baseline and post-resolution parameters were performed, and factors affecting change in visual acuity were analyzed. A significant decrease in RPE thickness and a significant increase in RPE reflectivity were seen following resolution of the disease. Furthermore, there was a significant correlation between RPE and choroidal thickness during the acute stage of the disease. Baseline visual acuity and the presence of bacillary detachment at baseline were the only factors responsible for changes in visual acuity. We propose the utility of RPE layer as a surrogate biomarker of choroidal activity and inflammation in terms of RPE reflectivity and RPE thickness during the acute stage of VKH, especially when there is poor imaging of the choroid. |
| first_indexed | 2024-03-11T06:21:50Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T06:21:50Z |
| publishDate | 2023-03-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1f33608a1cc3442b827a81c806dab5372023-11-17T11:51:53ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01126236810.3390/jcm12062368Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada DiseaseNinan Jacob0Mudit Tyagi1Jay Chhablani2Raja Narayanan3Anup Kelgaonkar4Mukesh Jain5Sumit Randhir Singh6Niroj Kumar Sahoo7Anant Bajaj Retina Institute, Kode Venkatadri Chowdary Campus, L V Prasad Eye Institute, Vijayawada 521134, IndiaAnant Bajaj Retina Institute, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad 500034, IndiaUPMC Eye Center, University of Pittsburgh, Pittsburgh, PA 15213, USAAnant Bajaj Retina Institute, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Hyderabad 500034, IndiaAnant Bajaj Retina Institute, Mithu Tulsi Chanrai Campus, L V Prasad Eye Institute, Bhubaneswar 751024, IndiaAnant Bajaj Retina Institute, Mithu Tulsi Chanrai Campus, L V Prasad Eye Institute, Bhubaneswar 751024, IndiaSri Sai Lions Netralaya and Sri Sai Eye Hospital, Patna 800020, IndiaAnant Bajaj Retina Institute, Kode Venkatadri Chowdary Campus, L V Prasad Eye Institute, Vijayawada 521134, IndiaVogt-Koyanagi-Harada (VKH) disease is an auto-immune inflammatory disease of choroidal origin. During the acute stage, optical coherence tomography (OCT), however, may not be able to assess the entire choroid. The aims of the paper were to evaluate the role of retinal pigment epithelium (RPE) as a biomarker of inflammation in acute VKH. This was a retrospective observational study done in 55 eyes of 29 patients with acute VKH. RPE thickness, total choroidal thickness, and RPE reflectivity before and after resolution were analyzed using image J software. Correlations between several baseline and post-resolution parameters were performed, and factors affecting change in visual acuity were analyzed. A significant decrease in RPE thickness and a significant increase in RPE reflectivity were seen following resolution of the disease. Furthermore, there was a significant correlation between RPE and choroidal thickness during the acute stage of the disease. Baseline visual acuity and the presence of bacillary detachment at baseline were the only factors responsible for changes in visual acuity. We propose the utility of RPE layer as a surrogate biomarker of choroidal activity and inflammation in terms of RPE reflectivity and RPE thickness during the acute stage of VKH, especially when there is poor imaging of the choroid.https://www.mdpi.com/2077-0383/12/6/2368Vogt-Koyanagi-Harada diseaseVKHretinal pigment epitheliumRPEOCToptical coherence tomography |
| spellingShingle | Ninan Jacob Mudit Tyagi Jay Chhablani Raja Narayanan Anup Kelgaonkar Mukesh Jain Sumit Randhir Singh Niroj Kumar Sahoo Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease Journal of Clinical Medicine Vogt-Koyanagi-Harada disease VKH retinal pigment epithelium RPE OCT optical coherence tomography |
| title | Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease |
| title_full | Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease |
| title_fullStr | Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease |
| title_full_unstemmed | Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease |
| title_short | Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease |
| title_sort | retinal pigment epithelial characteristics in acute and resolved vogt koyanagi harada disease |
| topic | Vogt-Koyanagi-Harada disease VKH retinal pigment epithelium RPE OCT optical coherence tomography |
| url | https://www.mdpi.com/2077-0383/12/6/2368 |
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