Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis.
A major complication of peritoneal dialysis is the development of peritonitis, which is associated with reduced technique and patient survival. The inflammatory response elicited by infection results in a fibrin and debris-rich environment within the peritoneal cavity, which may reduce the effective...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4351066?pdf=render |
| _version_ | 1818848271792078848 |
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| author | Amanda L McGuire Sophia C Bennett Sally M Lansley Natalia D Popowicz Julius F Varano della Vergiliana Daniel Wong Y C Gary Lee Aron Chakera |
| author_facet | Amanda L McGuire Sophia C Bennett Sally M Lansley Natalia D Popowicz Julius F Varano della Vergiliana Daniel Wong Y C Gary Lee Aron Chakera |
| author_sort | Amanda L McGuire |
| collection | DOAJ |
| description | A major complication of peritoneal dialysis is the development of peritonitis, which is associated with reduced technique and patient survival. The inflammatory response elicited by infection results in a fibrin and debris-rich environment within the peritoneal cavity, which may reduce the effectiveness of antimicrobial agents and predispose to recurrence or relapse of infection. Strategies to enhance responses to antimicrobial agents therefore have the potential to improve patient outcomes. This study presents pre-clinical data describing the compatibility of tPA and DNase in combination with antimicrobial agents used for the treatment of PD peritonitis. tPA and DNase were stable in standard dialysate solution and in the presence of antimicrobial agents, and were safe when given intraperitoneally in a mouse model with no evidence of local or systemic toxicity. Adjunctive tPA and DNase may have a role in the management of patients presenting with PD peritonitis. |
| first_indexed | 2024-12-19T06:14:42Z |
| format | Article |
| id | doaj.art-1f340ee4d83d4a14888d016b57c8c9fc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T06:14:42Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1f340ee4d83d4a14888d016b57c8c9fc2022-12-21T20:32:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011923810.1371/journal.pone.0119238Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis.Amanda L McGuireSophia C BennettSally M LansleyNatalia D PopowiczJulius F Varano della VergilianaDaniel WongY C Gary LeeAron ChakeraA major complication of peritoneal dialysis is the development of peritonitis, which is associated with reduced technique and patient survival. The inflammatory response elicited by infection results in a fibrin and debris-rich environment within the peritoneal cavity, which may reduce the effectiveness of antimicrobial agents and predispose to recurrence or relapse of infection. Strategies to enhance responses to antimicrobial agents therefore have the potential to improve patient outcomes. This study presents pre-clinical data describing the compatibility of tPA and DNase in combination with antimicrobial agents used for the treatment of PD peritonitis. tPA and DNase were stable in standard dialysate solution and in the presence of antimicrobial agents, and were safe when given intraperitoneally in a mouse model with no evidence of local or systemic toxicity. Adjunctive tPA and DNase may have a role in the management of patients presenting with PD peritonitis.http://europepmc.org/articles/PMC4351066?pdf=render |
| spellingShingle | Amanda L McGuire Sophia C Bennett Sally M Lansley Natalia D Popowicz Julius F Varano della Vergiliana Daniel Wong Y C Gary Lee Aron Chakera Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis. PLoS ONE |
| title | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis. |
| title_full | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis. |
| title_fullStr | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis. |
| title_full_unstemmed | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis. |
| title_short | Preclinical assessment of adjunctive tPA and DNase for peritoneal dialysis associated peritonitis. |
| title_sort | preclinical assessment of adjunctive tpa and dnase for peritoneal dialysis associated peritonitis |
| url | http://europepmc.org/articles/PMC4351066?pdf=render |
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