Visual task-related functional and structural magnetic resonance imaging for the objective quantitation of visual function in patients with advanced retinitis pigmentosa
PurposeThe objective quantitation of visual function in patients with advanced retinitis pigmentosa (RP) presents a difficult challenge due to the weak visual function of these patients. This study utilized magnetic resonance imaging (MRI) to assess the function and structure of the visual cortex (V...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.825204/full |
| _version_ | 1811216274078826496 |
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| author | Hao Wang Hao Wang Wangbin Ouyang Wangbin Ouyang Yong Liu Yong Liu Minfang Zhang Minfang Zhang He Zhao He Zhao Jian Wang Zhengqin Yin Zhengqin Yin |
| author_facet | Hao Wang Hao Wang Wangbin Ouyang Wangbin Ouyang Yong Liu Yong Liu Minfang Zhang Minfang Zhang He Zhao He Zhao Jian Wang Zhengqin Yin Zhengqin Yin |
| author_sort | Hao Wang |
| collection | DOAJ |
| description | PurposeThe objective quantitation of visual function in patients with advanced retinitis pigmentosa (RP) presents a difficult challenge due to the weak visual function of these patients. This study utilized magnetic resonance imaging (MRI) to assess the function and structure of the visual cortex (VC) in patients with RP and quantitatively categorize them.Materials and MethodsTwenty-three patients with RP and ten healthy controls (HCs) were enrolled for MRI examinations. The patients were divided into form perception (FP) and no form perception (NFP) groups. Participants underwent structural MRI scans, and two visual task functional MRI scans were performed using stimuli, including white flash and black and white checkerboard patterns. Eight regions of interest (ROIs) were studied. In structural MRI, the gray matter volume (GMV) was compared in the ROIs. In the two visual tasks, the response intensity and functional connectivity (FC) of ROIs were also compared separately. Correlation analysis was performed to explore the correlations between the structural and functional parameters.ResultsIn the structural analysis, the GMV in Brodmann areas 17, 18, and 19 of the FP and NFP groups was significantly lower than that of HCs. Regarding the functional data, the response intensity in the VC of both the FP and NFP groups was significantly lower than that in HCs. The response in Brodmann areas 17, 18, and 19 obtained using the pattern stimulus was significantly lower in the NFP group than in the FP group. For the FC comparison, the FP and NFP groups exhibited significantly lower values in several pathways than the HCs, and FC in the ipsilateral V1–contralateral V1 pathway in the flash task was significantly lower in the NFP group than in the FP group. A positive correlation between response intensity and GMV was observed in Brodmann areas 17, 18, and 19 in both flash and pattern visual tasks.ConclusionMagnetic resonance imaging was an effective tool to objectively and quantitatively evaluate the visual function of patients with advanced RP. Response intensity and FC were effective parameters to distinguish FP and NFP patients. A positive correlation between response intensity and GMV was observed in the VC. |
| first_indexed | 2024-04-12T06:35:26Z |
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| id | doaj.art-1f3435cf1dc64630b80e09fc8c9bb3e8 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-12T06:35:26Z |
| publishDate | 2022-07-01 |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-1f3435cf1dc64630b80e09fc8c9bb3e82022-12-22T03:43:52ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-07-011410.3389/fnagi.2022.825204825204Visual task-related functional and structural magnetic resonance imaging for the objective quantitation of visual function in patients with advanced retinitis pigmentosaHao Wang0Hao Wang1Wangbin Ouyang2Wangbin Ouyang3Yong Liu4Yong Liu5Minfang Zhang6Minfang Zhang7He Zhao8He Zhao9Jian Wang10Zhengqin Yin11Zhengqin Yin12Southwest Hospital/Southwest Eye Hospital, Army Medical University, Chongqing, ChinaKey Lab of Visual Damage and Regeneration and Restoration of Chongqing, Chongqing, ChinaSouthwest Hospital/Southwest Eye Hospital, Army Medical University, Chongqing, ChinaKey Lab of Visual Damage and Regeneration and Restoration of Chongqing, Chongqing, ChinaSouthwest Hospital/Southwest Eye Hospital, Army Medical University, Chongqing, ChinaKey Lab of Visual Damage and Regeneration and Restoration of Chongqing, Chongqing, ChinaSouthwest Hospital/Southwest Eye Hospital, Army Medical University, Chongqing, ChinaKey Lab of Visual Damage and Regeneration and Restoration of Chongqing, Chongqing, ChinaSouthwest Hospital/Southwest Eye Hospital, Army Medical University, Chongqing, ChinaKey Lab of Visual Damage and Regeneration and Restoration of Chongqing, Chongqing, ChinaDepartment of Radiology, Southwest Hospital, Army Medical University, Chongqing, ChinaSouthwest Hospital/Southwest Eye Hospital, Army Medical University, Chongqing, ChinaKey Lab of Visual Damage and Regeneration and Restoration of Chongqing, Chongqing, ChinaPurposeThe objective quantitation of visual function in patients with advanced retinitis pigmentosa (RP) presents a difficult challenge due to the weak visual function of these patients. This study utilized magnetic resonance imaging (MRI) to assess the function and structure of the visual cortex (VC) in patients with RP and quantitatively categorize them.Materials and MethodsTwenty-three patients with RP and ten healthy controls (HCs) were enrolled for MRI examinations. The patients were divided into form perception (FP) and no form perception (NFP) groups. Participants underwent structural MRI scans, and two visual task functional MRI scans were performed using stimuli, including white flash and black and white checkerboard patterns. Eight regions of interest (ROIs) were studied. In structural MRI, the gray matter volume (GMV) was compared in the ROIs. In the two visual tasks, the response intensity and functional connectivity (FC) of ROIs were also compared separately. Correlation analysis was performed to explore the correlations between the structural and functional parameters.ResultsIn the structural analysis, the GMV in Brodmann areas 17, 18, and 19 of the FP and NFP groups was significantly lower than that of HCs. Regarding the functional data, the response intensity in the VC of both the FP and NFP groups was significantly lower than that in HCs. The response in Brodmann areas 17, 18, and 19 obtained using the pattern stimulus was significantly lower in the NFP group than in the FP group. For the FC comparison, the FP and NFP groups exhibited significantly lower values in several pathways than the HCs, and FC in the ipsilateral V1–contralateral V1 pathway in the flash task was significantly lower in the NFP group than in the FP group. A positive correlation between response intensity and GMV was observed in Brodmann areas 17, 18, and 19 in both flash and pattern visual tasks.ConclusionMagnetic resonance imaging was an effective tool to objectively and quantitatively evaluate the visual function of patients with advanced RP. Response intensity and FC were effective parameters to distinguish FP and NFP patients. A positive correlation between response intensity and GMV was observed in the VC.https://www.frontiersin.org/articles/10.3389/fnagi.2022.825204/fulladvanced retinitis pigmentosafunctional magnetic resonance imagingvisual taskresponse intensityfunctional connectivitygray matter volume |
| spellingShingle | Hao Wang Hao Wang Wangbin Ouyang Wangbin Ouyang Yong Liu Yong Liu Minfang Zhang Minfang Zhang He Zhao He Zhao Jian Wang Zhengqin Yin Zhengqin Yin Visual task-related functional and structural magnetic resonance imaging for the objective quantitation of visual function in patients with advanced retinitis pigmentosa Frontiers in Aging Neuroscience advanced retinitis pigmentosa functional magnetic resonance imaging visual task response intensity functional connectivity gray matter volume |
| title | Visual task-related functional and structural magnetic resonance imaging for the objective quantitation of visual function in patients with advanced retinitis pigmentosa |
| title_full | Visual task-related functional and structural magnetic resonance imaging for the objective quantitation of visual function in patients with advanced retinitis pigmentosa |
| title_fullStr | Visual task-related functional and structural magnetic resonance imaging for the objective quantitation of visual function in patients with advanced retinitis pigmentosa |
| title_full_unstemmed | Visual task-related functional and structural magnetic resonance imaging for the objective quantitation of visual function in patients with advanced retinitis pigmentosa |
| title_short | Visual task-related functional and structural magnetic resonance imaging for the objective quantitation of visual function in patients with advanced retinitis pigmentosa |
| title_sort | visual task related functional and structural magnetic resonance imaging for the objective quantitation of visual function in patients with advanced retinitis pigmentosa |
| topic | advanced retinitis pigmentosa functional magnetic resonance imaging visual task response intensity functional connectivity gray matter volume |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.825204/full |
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