Structural insights into DNA N6-adenine methylation by the MTA1 complex

Structural insights into DNA N6-adenine methylation by the MTA1 complex

Abstract N6-methyldeoxyadenine (6mA) has recently been reported as a prevalent DNA modification in eukaryotes. The Tetrahymena thermophila MTA1 complex consisting of four subunits, namely MTA1, MTA9, p1, and p2, is the first identified eukaryotic 6mA methyltransferase (MTase) complex. Unlike the pro...

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Bibliographic Details
Main Authors: Junjun Yan, Feiqing Liu, Zeyuan Guan, Xuhui Yan, Xiaohuan Jin, Qiang Wang, Zican Wang, Junjie Yan, Delin Zhang, Zhu Liu, Shan Wu, Ping Yin
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-022-00516-w

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