MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation
Differentiating stem cells must adapt their mitochondrial metabolism to fit the needs of the mature differentiated cell. In a recent study, we observed that during differentiation to an endothelial phenotype, pluripotent stem cell mitochondria are removed by mitophagy, triggering compensatory mitoch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Autophagy Reports |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/27694127.2022.2071549 |
| _version_ | 1827818513411080192 |
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| author | Priyanka Gajwani Jalees Rehman |
| author_facet | Priyanka Gajwani Jalees Rehman |
| author_sort | Priyanka Gajwani |
| collection | DOAJ |
| description | Differentiating stem cells must adapt their mitochondrial metabolism to fit the needs of the mature differentiated cell. In a recent study, we observed that during differentiation to an endothelial phenotype, pluripotent stem cell mitochondria are removed by mitophagy, triggering compensatory mitochondrial biogenesis to replenish the mitochondrial pool. We identified the mitochondrial phosphatase PGAM5 as the link between mitophagy and transcription of the mitochondrial biogenesis regulator PPARGC1A/PGC1α in the nucleus. Swapping of mitochondria through the coupled processes of mitophagy and mitochondrial biogenesis lead to enhanced metabolic reprogramming in the differentiated cell. |
| first_indexed | 2024-03-12T00:54:57Z |
| format | Article |
| id | doaj.art-1f3563376ea047729a2c74752fa9f449 |
| institution | Directory Open Access Journal |
| issn | 2769-4127 |
| language | English |
| last_indexed | 2024-03-12T00:54:57Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Autophagy Reports |
| spelling | doaj.art-1f3563376ea047729a2c74752fa9f4492023-09-14T13:24:40ZengTaylor & Francis GroupAutophagy Reports2769-41272022-12-011121021310.1080/27694127.2022.20715492071549MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiationPriyanka Gajwani0Jalees Rehman1University of Illinois, College of MedicineUniversity of Illinois, College of MedicineDifferentiating stem cells must adapt their mitochondrial metabolism to fit the needs of the mature differentiated cell. In a recent study, we observed that during differentiation to an endothelial phenotype, pluripotent stem cell mitochondria are removed by mitophagy, triggering compensatory mitochondrial biogenesis to replenish the mitochondrial pool. We identified the mitochondrial phosphatase PGAM5 as the link between mitophagy and transcription of the mitochondrial biogenesis regulator PPARGC1A/PGC1α in the nucleus. Swapping of mitochondria through the coupled processes of mitophagy and mitochondrial biogenesis lead to enhanced metabolic reprogramming in the differentiated cell.http://dx.doi.org/10.1080/27694127.2022.2071549ctnnb1/β-catenindifferentiationendotheliummitochondrial biogenesismitofusin 2mitophagypink1ppargc1a/pgc1αstem cells |
| spellingShingle | Priyanka Gajwani Jalees Rehman MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation Autophagy Reports ctnnb1/β-catenin differentiation endothelium mitochondrial biogenesis mitofusin 2 mitophagy pink1 ppargc1a/pgc1α stem cells |
| title | MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation |
| title_full | MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation |
| title_fullStr | MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation |
| title_full_unstemmed | MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation |
| title_short | MitoSwap – Mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation |
| title_sort | mitoswap mitophagy partnered with compensatory mitochondrial biogenesis during stem cell differentiation |
| topic | ctnnb1/β-catenin differentiation endothelium mitochondrial biogenesis mitofusin 2 mitophagy pink1 ppargc1a/pgc1α stem cells |
| url | http://dx.doi.org/10.1080/27694127.2022.2071549 |
| work_keys_str_mv | AT priyankagajwani mitoswapmitophagypartneredwithcompensatorymitochondrialbiogenesisduringstemcelldifferentiation AT jaleesrehman mitoswapmitophagypartneredwithcompensatorymitochondrialbiogenesisduringstemcelldifferentiation |