Large tumor suppressors 1 and 2 regulate Aurora-B through phosphorylation of INCENP to ensure completion of cytokinesis

Large tumor suppressors 1 and 2 regulate Aurora-B through phosphorylation of INCENP to ensure completion of cytokinesis

The tumor suppressor kinases LATS1 and LATS2 (LATS1/2) regulate not only organ size through the Hippo signaling pathway, but also cell-cycle checkpoints and apoptosis via other signaling cascades. We previously reported that LATS1/2 localize to the mitotic apparatus, where they are involved in the p...

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Bibliographic Details
Main Authors: Norikazu Yabuta, Kaori Yoshida, Satomi Mukai, Yorika Kato, Kosuke Torigata, Hiroshi Nojima
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Heliyon
Subjects:
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844016304261

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