Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and Men
Small GTPases are molecular switches that participate in many essential cellular processes. Amongst them, human Rac1 was first described for its role in regulating actin cytoskeleton dynamics and cell migration, with a close relation to carcinogenesis. More recently, the role of Rac1 in regulating t...
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| Format: | Article |
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MDPI AG
2024-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/6/472 |
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| author | Linnet Bischof Franziska Schweitzer Jürgen J. Heinisch |
| author_facet | Linnet Bischof Franziska Schweitzer Jürgen J. Heinisch |
| author_sort | Linnet Bischof |
| collection | DOAJ |
| description | Small GTPases are molecular switches that participate in many essential cellular processes. Amongst them, human Rac1 was first described for its role in regulating actin cytoskeleton dynamics and cell migration, with a close relation to carcinogenesis. More recently, the role of Rac1 in regulating the production of reactive oxygen species (ROS), both as a subunit of NADPH oxidase complexes and through its association with mitochondrial functions, has drawn attention. Malfunctions in this context affect cellular plasticity and apoptosis, related to neurodegenerative diseases and diabetes. Some of these features of Rac1 are conserved in its yeast homologue Rho5. Here, we review the structural and functional similarities and differences between these two evolutionary distant proteins and propose yeast as a useful model and a device for high-throughput screens for specific drugs. |
| first_indexed | 2024-04-24T18:26:29Z |
| format | Article |
| id | doaj.art-1f38b39022834d6fa81c5c8b859b6138 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-04-24T18:26:29Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-1f38b39022834d6fa81c5c8b859b61382024-03-27T13:30:30ZengMDPI AGCells2073-44092024-03-0113647210.3390/cells13060472Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and MenLinnet Bischof0Franziska Schweitzer1Jürgen J. Heinisch2AG Genetik, Fachbereich Biologie/Chemie, University of Osnabrück, Barbarastrasse 11, D-49076 Osnabrück, GermanyAG Genetik, Fachbereich Biologie/Chemie, University of Osnabrück, Barbarastrasse 11, D-49076 Osnabrück, GermanyAG Genetik, Fachbereich Biologie/Chemie, University of Osnabrück, Barbarastrasse 11, D-49076 Osnabrück, GermanySmall GTPases are molecular switches that participate in many essential cellular processes. Amongst them, human Rac1 was first described for its role in regulating actin cytoskeleton dynamics and cell migration, with a close relation to carcinogenesis. More recently, the role of Rac1 in regulating the production of reactive oxygen species (ROS), both as a subunit of NADPH oxidase complexes and through its association with mitochondrial functions, has drawn attention. Malfunctions in this context affect cellular plasticity and apoptosis, related to neurodegenerative diseases and diabetes. Some of these features of Rac1 are conserved in its yeast homologue Rho5. Here, we review the structural and functional similarities and differences between these two evolutionary distant proteins and propose yeast as a useful model and a device for high-throughput screens for specific drugs.https://www.mdpi.com/2073-4409/13/6/472Rac1Rho5molecular switchoxidative stressglucose signalingmitochondria |
| spellingShingle | Linnet Bischof Franziska Schweitzer Jürgen J. Heinisch Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and Men Cells Rac1 Rho5 molecular switch oxidative stress glucose signaling mitochondria |
| title | Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and Men |
| title_full | Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and Men |
| title_fullStr | Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and Men |
| title_full_unstemmed | Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and Men |
| title_short | Functional Conservation of the Small GTPase Rho5/Rac1—A Tale of Yeast and Men |
| title_sort | functional conservation of the small gtpase rho5 rac1 a tale of yeast and men |
| topic | Rac1 Rho5 molecular switch oxidative stress glucose signaling mitochondria |
| url | https://www.mdpi.com/2073-4409/13/6/472 |
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