The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and LymphangiogenesisSummary
The lymphatic vascular system has been minimally explored in the liver despite its essential functions including maintenance of tissue fluid homeostasis. The discovery of specific markers for lymphatic endothelial cells has advanced the study of lymphatics by methods including imaging, cell isolatio...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-11-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X16301035 |
| _version_ | 1818469524168507392 |
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| author | Masatake Tanaka Yasuko Iwakiri |
| author_facet | Masatake Tanaka Yasuko Iwakiri |
| author_sort | Masatake Tanaka |
| collection | DOAJ |
| description | The lymphatic vascular system has been minimally explored in the liver despite its essential functions including maintenance of tissue fluid homeostasis. The discovery of specific markers for lymphatic endothelial cells has advanced the study of lymphatics by methods including imaging, cell isolation, and transgenic animal models and has resulted in rapid progress in lymphatic vascular research during the last decade. These studies have yielded concrete evidence that lymphatic vessel dysfunction plays an important role in the pathogenesis of many diseases. This article reviews the current knowledge of the structure, function, and markers of the hepatic lymphatic vascular system as well as factors associated with hepatic lymphangiogenesis and compares liver lymphatics with those in other tissues. Keywords: VEGF, Inflammation, Cirrhosis, Portal Hypertension |
| first_indexed | 2024-04-13T21:25:39Z |
| format | Article |
| id | doaj.art-1f399e278dbe4ded925b46f7d7435613 |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-04-13T21:25:39Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-1f399e278dbe4ded925b46f7d74356132022-12-22T02:29:20ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2016-11-0126733749The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and LymphangiogenesisSummaryMasatake Tanaka0Yasuko Iwakiri1Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, ConnecticutReprint requests Address requests for reprints to: Yasuko Iwakiri, PhD, Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, TAC S223B, 333 Cedar Street, New Haven, Connecticut 06520. fax: (203) 785-7273.; Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, ConnecticutThe lymphatic vascular system has been minimally explored in the liver despite its essential functions including maintenance of tissue fluid homeostasis. The discovery of specific markers for lymphatic endothelial cells has advanced the study of lymphatics by methods including imaging, cell isolation, and transgenic animal models and has resulted in rapid progress in lymphatic vascular research during the last decade. These studies have yielded concrete evidence that lymphatic vessel dysfunction plays an important role in the pathogenesis of many diseases. This article reviews the current knowledge of the structure, function, and markers of the hepatic lymphatic vascular system as well as factors associated with hepatic lymphangiogenesis and compares liver lymphatics with those in other tissues. Keywords: VEGF, Inflammation, Cirrhosis, Portal Hypertensionhttp://www.sciencedirect.com/science/article/pii/S2352345X16301035 |
| spellingShingle | Masatake Tanaka Yasuko Iwakiri The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and LymphangiogenesisSummary Cellular and Molecular Gastroenterology and Hepatology |
| title | The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and LymphangiogenesisSummary |
| title_full | The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and LymphangiogenesisSummary |
| title_fullStr | The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and LymphangiogenesisSummary |
| title_full_unstemmed | The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and LymphangiogenesisSummary |
| title_short | The Hepatic Lymphatic Vascular System: Structure, Function, Markers, and LymphangiogenesisSummary |
| title_sort | hepatic lymphatic vascular system structure function markers and lymphangiogenesissummary |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X16301035 |
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