Synthesis of single stereoisomers of 2,2-disubstituted 3-hydroxycyclohexane-1-ones via enzymatic desymmetric reduction of the 1,3-cyclohexanediones
Chiral 3-hydroxycyclohexane-1-ones are widely used as building blocks in the synthesis of natural products and bioactive compounds, and preparation of their single stereoisomers is still quite challenging. Through screening the available carbonyl reductases, two enzymes were found to catalyze the de...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co. Ltd.
2021-08-01
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| Series: | Green Synthesis and Catalysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666554921000405 |