Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer

Temporally specific gene expression and chromatin remodeling programs regulate a conserved Pdyn enhancer

Neuronal and behavioral adaptations to novel stimuli are regulated by temporally dynamic waves of transcriptional activity, which shape neuronal function and guide enduring plasticity. Neuronal activation promotes expression of an immediate early gene (IEG) program comprised primarily of activity-de...

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Bibliographic Details
Main Authors: Robert A Phillips, Ethan Wan, Jennifer J Tuscher, David Reid, Olivia R Drake, Lara Ianov, Jeremy J Day
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-11-01
Series:eLife
Subjects:
transcription
gene regulation
striatum
enhancer
chromatin
CRISPR
Online Access:https://elifesciences.org/articles/89993

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