Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh
Objective: To compare Knodell and HAI scores in patients with wild type and pre-core/core promoter mutant CHB to see if there is any difference in severity of liver injury between these two types of HBV. Methods: We did percutaneous liver biopsies of 155 CHB patients. Of them 102 (65.8%) were infect...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Journal of Acute Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S222161891360133X |
| _version_ | 1818847977075113984 |
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| author | Ayub Al Mamun Mamun-Al-Mahtab S.M. Fazle Akbar Kutub Uddin Mollick Arun Jyoti Tarafdar Faiz Ahmad Khondokar Ahmed Lutful Mubin Md. Helal Uddin Salimur Rahman |
| author_facet | Ayub Al Mamun Mamun-Al-Mahtab S.M. Fazle Akbar Kutub Uddin Mollick Arun Jyoti Tarafdar Faiz Ahmad Khondokar Ahmed Lutful Mubin Md. Helal Uddin Salimur Rahman |
| author_sort | Ayub Al Mamun |
| collection | DOAJ |
| description | Objective: To compare Knodell and HAI scores in patients with wild type and pre-core/core promoter mutant CHB to see if there is any difference in severity of liver injury between these two types of HBV.
Methods: We did percutaneous liver biopsies of 155 CHB patients. Of them 102 (65.8%) were infected wild type HBV and the rest 53 (34.2%) were infected with pre-core/core promoter mutant CHB.
Results: 11/53 (20.8%) patients with pre-core/core promoter mutant CHB had moderate to severe CH (HAI score 8-18). In contrast, moderate to severe CH was seen in 19/102 (18.6%) patients with wild type CHB. Fibrosis score was >2 in 15/53 (28.3%) pre-core/core promoter mutant CHB as opposed to 20/102 (19.6%) patients with wild type CHB.
Conclusions: The study shows that pre-core/core promoter mutant HBV produces more severe histological liver disease compared to wild type HBV. |
| first_indexed | 2024-12-19T06:10:01Z |
| format | Article |
| id | doaj.art-1f3bbf535337466985f9d04209b690fd |
| institution | Directory Open Access Journal |
| issn | 2221-6189 |
| language | English |
| last_indexed | 2024-12-19T06:10:01Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Acute Disease |
| spelling | doaj.art-1f3bbf535337466985f9d04209b690fd2022-12-21T20:33:02ZengWolters Kluwer Medknow PublicationsJournal of Acute Disease2221-61892013-01-012323223510.1016/S2221-6189(13)60133-XStudy of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from BangladeshAyub Al Mamun0Mamun-Al-Mahtab1S.M. Fazle Akbar2Kutub Uddin Mollick3Arun Jyoti Tarafdar4Faiz Ahmad Khondokar5Ahmed Lutful Mubin6Md. Helal Uddin7Salimur Rahman8Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshDepartment of Medical Sciences, Toshiba General Hospital, Tokyo, JapanDepartment of Hepatology, Sir Salimullah Medical College, Dhaka, BangladeshDepartment of Hepatology, Mymensingh Medical College, Mymensingh, BangladeshDepartment of Medicine, Sadar Hospital, Noakhali, BangladeshDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshClinical Research Organization, Dhaka, BangladeshDepartment of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshObjective: To compare Knodell and HAI scores in patients with wild type and pre-core/core promoter mutant CHB to see if there is any difference in severity of liver injury between these two types of HBV. Methods: We did percutaneous liver biopsies of 155 CHB patients. Of them 102 (65.8%) were infected wild type HBV and the rest 53 (34.2%) were infected with pre-core/core promoter mutant CHB. Results: 11/53 (20.8%) patients with pre-core/core promoter mutant CHB had moderate to severe CH (HAI score 8-18). In contrast, moderate to severe CH was seen in 19/102 (18.6%) patients with wild type CHB. Fibrosis score was >2 in 15/53 (28.3%) pre-core/core promoter mutant CHB as opposed to 20/102 (19.6%) patients with wild type CHB. Conclusions: The study shows that pre-core/core promoter mutant HBV produces more severe histological liver disease compared to wild type HBV.http://www.sciencedirect.com/science/article/pii/S222161891360133XHistomorphologyHBVHBeAg |
| spellingShingle | Ayub Al Mamun Mamun-Al-Mahtab S.M. Fazle Akbar Kutub Uddin Mollick Arun Jyoti Tarafdar Faiz Ahmad Khondokar Ahmed Lutful Mubin Md. Helal Uddin Salimur Rahman Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh Journal of Acute Disease Histomorphology HBV HBeAg |
| title | Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh |
| title_full | Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh |
| title_fullStr | Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh |
| title_full_unstemmed | Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh |
| title_short | Study of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh |
| title_sort | study of hepatic histomorphology in hbeag and hbeag patients with chb experience from bangladesh |
| topic | Histomorphology HBV HBeAg |
| url | http://www.sciencedirect.com/science/article/pii/S222161891360133X |
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