How long were older people expected to live with or without sarcopenia? Multistate modeling of a national cohort study
ObjectivesSarcopenia is well known to be associated with mortality, but there is a lack of evidence on the estimates of life expectancy (LE) for sarcopenia in China. This study aims to estimate total life expectancy (TLE) and sarcopenia-specific LE in community-dwelling older Chinese adults with and...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1203203/full |
| _version_ | 1797685281666629632 |
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| author | Bo Ye Yujie Wang Jixiang Xu Junjia Jiang Shitong Yang Jie Chen Zhijun Bao Junling Gao Junling Gao Junling Gao |
| author_facet | Bo Ye Yujie Wang Jixiang Xu Junjia Jiang Shitong Yang Jie Chen Zhijun Bao Junling Gao Junling Gao Junling Gao |
| author_sort | Bo Ye |
| collection | DOAJ |
| description | ObjectivesSarcopenia is well known to be associated with mortality, but there is a lack of evidence on the estimates of life expectancy (LE) for sarcopenia in China. This study aims to estimate total life expectancy (TLE) and sarcopenia-specific LE in community-dwelling older Chinese adults with and without sarcopenia.MethodsThis study included participants aged 60 years and older who enrolled in the cohort in 2011 and 2013 and at least completed one follow-up until 2015 as part of the China Health and Retirement Longitudinal Study (CHARLS). The criteria for defining sarcopenia were based on the guidelines established by the Asian Working Group on Sarcopenia in 2019. TLE and sarcopenia-specific LE were estimated for the total population and subgroups using continuous-time multistate modeling.ResultsA total of 6,029 participants (49.2% women) with an average age of 68.4 (SD: 6.56) years were included in the study. The baseline prevalence of sarcopenia and possible sarcopenia was 19.5 and 44.9%, respectively. We observed that sarcopenia stages naturally deteriorated to worse stages (including death, by 24.4%) and returned to better stages (17.1%) during a median follow-up of 3.92 years (IQR: 2.00 ~ 4.00). The average TLE at the age of 60 was 20.9 [95% CI: 20.2–21.5] years (22.1 [95% CI: 19.6–24.6] for non-sarcopenic older adults, 20.9 [95% CI: 19.5–22.3] for possible sarcopenic, and 18.7 [95% CI: 16.4–21.1] for sarcopenic). Men, former and current smokers, and those living in northwest China had less TLE. Sarcopenic older adults, those with lower education, those who are unmarried, those with agriculture hukou, and those living in rural and northwest China were expected to live fewer years with non-sarcopenia. Sarcopenic older people, men, those with agriculture hukou, and those living in rural and southwest China were expected to live more years with sarcopenia.DiscussionThe results improved our understanding of the relationship between sarcopenia and life expectancy. We suggested that targeted strategies should be considered in high-risk populations and underdeveloped regions to prevent sarcopenia and improve non-sarcopenic life years for the older population. |
| first_indexed | 2024-03-12T00:41:56Z |
| format | Article |
| id | doaj.art-1f3e5655efea48cc802e531511592305 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-12T00:41:56Z |
| publishDate | 2023-09-01 |
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| spelling | doaj.art-1f3e5655efea48cc802e5315115923052023-09-15T03:25:59ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-09-011110.3389/fpubh.2023.12032031203203How long were older people expected to live with or without sarcopenia? Multistate modeling of a national cohort studyBo Ye0Yujie Wang1Jixiang Xu2Junjia Jiang3Shitong Yang4Jie Chen5Zhijun Bao6Junling Gao7Junling Gao8Junling Gao9Huadong Hospital, Fudan University, Shanghai, ChinaSchool of Public Health, Fudan University, Shanghai, ChinaSchool of Public Health, Fudan University, Shanghai, ChinaSchool of Public Health, Fudan University, Shanghai, ChinaSchool of Public Health, Fudan University, Shanghai, ChinaHuadong Hospital, Fudan University, Shanghai, ChinaHuadong Hospital, Fudan University, Shanghai, ChinaSchool of Public Health, Fudan University, Shanghai, ChinaCollaborative Innovation Cooperative Unit of National Clinical, Shanghai, ChinaCore Unit of Shanghai Clinical Research Center for Geriatric, Shanghai, ChinaObjectivesSarcopenia is well known to be associated with mortality, but there is a lack of evidence on the estimates of life expectancy (LE) for sarcopenia in China. This study aims to estimate total life expectancy (TLE) and sarcopenia-specific LE in community-dwelling older Chinese adults with and without sarcopenia.MethodsThis study included participants aged 60 years and older who enrolled in the cohort in 2011 and 2013 and at least completed one follow-up until 2015 as part of the China Health and Retirement Longitudinal Study (CHARLS). The criteria for defining sarcopenia were based on the guidelines established by the Asian Working Group on Sarcopenia in 2019. TLE and sarcopenia-specific LE were estimated for the total population and subgroups using continuous-time multistate modeling.ResultsA total of 6,029 participants (49.2% women) with an average age of 68.4 (SD: 6.56) years were included in the study. The baseline prevalence of sarcopenia and possible sarcopenia was 19.5 and 44.9%, respectively. We observed that sarcopenia stages naturally deteriorated to worse stages (including death, by 24.4%) and returned to better stages (17.1%) during a median follow-up of 3.92 years (IQR: 2.00 ~ 4.00). The average TLE at the age of 60 was 20.9 [95% CI: 20.2–21.5] years (22.1 [95% CI: 19.6–24.6] for non-sarcopenic older adults, 20.9 [95% CI: 19.5–22.3] for possible sarcopenic, and 18.7 [95% CI: 16.4–21.1] for sarcopenic). Men, former and current smokers, and those living in northwest China had less TLE. Sarcopenic older adults, those with lower education, those who are unmarried, those with agriculture hukou, and those living in rural and northwest China were expected to live fewer years with non-sarcopenia. Sarcopenic older people, men, those with agriculture hukou, and those living in rural and southwest China were expected to live more years with sarcopenia.DiscussionThe results improved our understanding of the relationship between sarcopenia and life expectancy. We suggested that targeted strategies should be considered in high-risk populations and underdeveloped regions to prevent sarcopenia and improve non-sarcopenic life years for the older population.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1203203/fullsarcopeniapossible sarcopenialife expectancymultistate modeltransitions |
| spellingShingle | Bo Ye Yujie Wang Jixiang Xu Junjia Jiang Shitong Yang Jie Chen Zhijun Bao Junling Gao Junling Gao Junling Gao How long were older people expected to live with or without sarcopenia? Multistate modeling of a national cohort study Frontiers in Public Health sarcopenia possible sarcopenia life expectancy multistate model transitions |
| title | How long were older people expected to live with or without sarcopenia? Multistate modeling of a national cohort study |
| title_full | How long were older people expected to live with or without sarcopenia? Multistate modeling of a national cohort study |
| title_fullStr | How long were older people expected to live with or without sarcopenia? Multistate modeling of a national cohort study |
| title_full_unstemmed | How long were older people expected to live with or without sarcopenia? Multistate modeling of a national cohort study |
| title_short | How long were older people expected to live with or without sarcopenia? Multistate modeling of a national cohort study |
| title_sort | how long were older people expected to live with or without sarcopenia multistate modeling of a national cohort study |
| topic | sarcopenia possible sarcopenia life expectancy multistate model transitions |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1203203/full |
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