Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis
Psoriasis is a common autoimmune inflammatory disease wherein pathogenesis is advanced by fundamental genetic predisposition/s in concert with environmental triggers. Inflammation in psoriasis may represent efforts of innate immune system to target pathogens for restoring immune homeostasis. Aberran...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Biomedical Research Journal |
| Subjects: | |
| Online Access: | http://www.brjnmims.org/article.asp?issn=2349-3666;year=2015;volume=2;issue=2;spage=220;epage=232;aulast=Pandey;type=0 |
| _version_ | 1818958420227653632 |
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| author | Garima Pandey Abhay Kumar Pandey S S Pandey B L Pandey |
| author_facet | Garima Pandey Abhay Kumar Pandey S S Pandey B L Pandey |
| author_sort | Garima Pandey |
| collection | DOAJ |
| description | Psoriasis is a common autoimmune inflammatory disease wherein pathogenesis is advanced by fundamental genetic predisposition/s in concert with environmental triggers. Inflammation in psoriasis may represent efforts of innate immune system to target pathogens for restoring immune homeostasis. Aberrant microbiota may resist elimination efforts by shear advantage of several fold gene pool as compared to the host. The microbes deregulate gene expression by the molecular insults targeting host immune system. Role of microbiota in autoimmunity dictates establishment of microbiome homeostasis and suppress host immune response; as a treatment approach. Dietary prebiotics and probiotics are of particular interest for prevention and amelioration of autoimmune inflammatory diseases, due to their potential to foster healthy host-microbiome relationship. The rational dietetics aims towards balancing friendly versus enemical microbes via manipulation of gut environment and modulation of immune system to improve regulation of inflammatory and autoimmune mechanisms. |
| first_indexed | 2024-12-20T11:25:27Z |
| format | Article |
| id | doaj.art-1f428293addf4d71b5929cc1c304c696 |
| institution | Directory Open Access Journal |
| issn | 2349-3666 2349-3674 |
| language | English |
| last_indexed | 2024-12-20T11:25:27Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Biomedical Research Journal |
| spelling | doaj.art-1f428293addf4d71b5929cc1c304c6962022-12-21T19:42:23ZengWolters Kluwer Medknow PublicationsBiomedical Research Journal2349-36662349-36742015-01-012222023210.4103/2349-3666.240656Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasisGarima PandeyAbhay Kumar PandeyS S PandeyB L PandeyPsoriasis is a common autoimmune inflammatory disease wherein pathogenesis is advanced by fundamental genetic predisposition/s in concert with environmental triggers. Inflammation in psoriasis may represent efforts of innate immune system to target pathogens for restoring immune homeostasis. Aberrant microbiota may resist elimination efforts by shear advantage of several fold gene pool as compared to the host. The microbes deregulate gene expression by the molecular insults targeting host immune system. Role of microbiota in autoimmunity dictates establishment of microbiome homeostasis and suppress host immune response; as a treatment approach. Dietary prebiotics and probiotics are of particular interest for prevention and amelioration of autoimmune inflammatory diseases, due to their potential to foster healthy host-microbiome relationship. The rational dietetics aims towards balancing friendly versus enemical microbes via manipulation of gut environment and modulation of immune system to improve regulation of inflammatory and autoimmune mechanisms.http://www.brjnmims.org/article.asp?issn=2349-3666;year=2015;volume=2;issue=2;spage=220;epage=232;aulast=Pandey;type=0psoriasisautoimmunitymicrobiotadysbiosisendotoxinsepigeneticsuperantigens |
| spellingShingle | Garima Pandey Abhay Kumar Pandey S S Pandey B L Pandey Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis Biomedical Research Journal psoriasis autoimmunity microbiota dysbiosis endotoxins epigenetic superantigens |
| title | Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis |
| title_full | Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis |
| title_fullStr | Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis |
| title_full_unstemmed | Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis |
| title_short | Microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis |
| title_sort | microbiota in immune pathogenesis and the prospects for pre and probiotic dietetics in psoriasis |
| topic | psoriasis autoimmunity microbiota dysbiosis endotoxins epigenetic superantigens |
| url | http://www.brjnmims.org/article.asp?issn=2349-3666;year=2015;volume=2;issue=2;spage=220;epage=232;aulast=Pandey;type=0 |
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