Penetration Enhancers in Ocular Drug Delivery
There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science. One of the ways to improve drug delivery to the eye is the use of penetration enhancers. These are defined as compounds capable of enhanci...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/11/7/321 |
| _version_ | 1817990733632634880 |
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| author | Roman V. Moiseev Peter W. J. Morrison Fraser Steele Vitaliy V. Khutoryanskiy |
| author_facet | Roman V. Moiseev Peter W. J. Morrison Fraser Steele Vitaliy V. Khutoryanskiy |
| author_sort | Roman V. Moiseev |
| collection | DOAJ |
| description | There are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science. One of the ways to improve drug delivery to the eye is the use of penetration enhancers. These are defined as compounds capable of enhancing drug permeability across ocular membranes. This review paper provides an overview of anatomical and physiological features of the eye and discusses some common ophthalmological conditions and permeability of ocular membranes. The review also presents the analysis of literature on the use of penetration-enhancing compounds (cyclodextrins, chelating agents, crown ethers, bile acids and bile salts, cell-penetrating peptides, and other amphiphilic compounds) in ocular drug delivery, describing their properties and modes of action. |
| first_indexed | 2024-04-14T01:03:06Z |
| format | Article |
| id | doaj.art-1f42cd4f4f524633bf4f8480d46c9aec |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-14T01:03:06Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-1f42cd4f4f524633bf4f8480d46c9aec2022-12-22T02:21:20ZengMDPI AGPharmaceutics1999-49232019-07-0111732110.3390/pharmaceutics11070321pharmaceutics11070321Penetration Enhancers in Ocular Drug DeliveryRoman V. Moiseev0Peter W. J. Morrison1Fraser Steele2Vitaliy V. Khutoryanskiy3Reading School of Pharmacy, University of Reading, Whiteknights, P.O. Box 224, Reading RG66AD, UKReading School of Pharmacy, University of Reading, Whiteknights, P.O. Box 224, Reading RG66AD, UKMC2 Therapeutics, James House, Emlyn Lane, Leatherhead KT22 7EP, UKReading School of Pharmacy, University of Reading, Whiteknights, P.O. Box 224, Reading RG66AD, UKThere are more than 100 recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science. One of the ways to improve drug delivery to the eye is the use of penetration enhancers. These are defined as compounds capable of enhancing drug permeability across ocular membranes. This review paper provides an overview of anatomical and physiological features of the eye and discusses some common ophthalmological conditions and permeability of ocular membranes. The review also presents the analysis of literature on the use of penetration-enhancing compounds (cyclodextrins, chelating agents, crown ethers, bile acids and bile salts, cell-penetrating peptides, and other amphiphilic compounds) in ocular drug delivery, describing their properties and modes of action.https://www.mdpi.com/1999-4923/11/7/321ocular drug deliverycorneapenetration enhancersocular conditionsophthalmology |
| spellingShingle | Roman V. Moiseev Peter W. J. Morrison Fraser Steele Vitaliy V. Khutoryanskiy Penetration Enhancers in Ocular Drug Delivery Pharmaceutics ocular drug delivery cornea penetration enhancers ocular conditions ophthalmology |
| title | Penetration Enhancers in Ocular Drug Delivery |
| title_full | Penetration Enhancers in Ocular Drug Delivery |
| title_fullStr | Penetration Enhancers in Ocular Drug Delivery |
| title_full_unstemmed | Penetration Enhancers in Ocular Drug Delivery |
| title_short | Penetration Enhancers in Ocular Drug Delivery |
| title_sort | penetration enhancers in ocular drug delivery |
| topic | ocular drug delivery cornea penetration enhancers ocular conditions ophthalmology |
| url | https://www.mdpi.com/1999-4923/11/7/321 |
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