Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants
Background: Survivors of preterm birth are at risk of long-term respiratory consequences. The objective of this prospective study was to assess pulmonary function at preschool age of former very low birth weight (VLBW) preterm children.Methods: Lung function of children born preterm and term control...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.577673/full |
| _version_ | 1818408217395331072 |
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| author | Hung-Yang Chang Hung-Yang Chang Jui-Hsing Chang Jui-Hsing Chang Hsin Chi Hsin Chi Chyong-Hsin Hsu Chia-Ying Lin Wai-Tim Jim Chun-Chih Peng Chun-Chih Peng |
| author_facet | Hung-Yang Chang Hung-Yang Chang Jui-Hsing Chang Jui-Hsing Chang Hsin Chi Hsin Chi Chyong-Hsin Hsu Chia-Ying Lin Wai-Tim Jim Chun-Chih Peng Chun-Chih Peng |
| author_sort | Hung-Yang Chang |
| collection | DOAJ |
| description | Background: Survivors of preterm birth are at risk of long-term respiratory consequences. The objective of this prospective study was to assess pulmonary function at preschool age of former very low birth weight (VLBW) preterm children.Methods: Lung function of children born preterm and term controls aged 5–6 years were assessed by spirometry. The results were converted to z-scores. A questionnaire regarding respiratory symptoms was completed. Associations to gestational age (GA), birth weight (BW), bronchopulmonary dysplasia (BPD), and perinatal factors were assessed.Results: In total, 85 VLBW preterm children and 29 term controls were studied. Of the preterm children, the mean GA was 28.6 ± 2.6 weeks and the mean BW was 1,047 ± 273 gm. Preterm children had significantly lower z-scores of forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC) ratio, and forced expiratory flow rate between 25–75% of FVC (FEF25−75), compared with term controls (−0.73 vs. 0.04, p = 0.002; −0.22 vs. 0.39, p = 0.003; −0.93 vs. 0.0, p < 0.001; respectively). Further segregation of the preterm group revealed significantly impaired FEV1, FEF25−75 in children at earlier gestation (≤ 28 weeks, n = 45), lighter at birth (≤ 1,000 g, n = 38), or with BPD (n = 55) compared with term controls (p < 0.05). There were significant negative relationships between the severity of BPD with FEV1, FVC, and FEF25−75 (p < 0.05). However, no correlation between lung function measurements and respiratory symptoms was found.Conclusions: VLBW preterm infants have reduced lung function at preschool age, especially among those with younger GA, lower BW, and BPD. Additional long-term follow-up of respiratory outcomes are needed for this vulnerable population. |
| first_indexed | 2024-12-14T09:40:13Z |
| format | Article |
| id | doaj.art-1f434d41882e48d2bf93cab6914fdb79 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-14T09:40:13Z |
| publishDate | 2020-09-01 |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-1f434d41882e48d2bf93cab6914fdb792022-12-21T23:07:48ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-09-01810.3389/fped.2020.577673577673Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm InfantsHung-Yang Chang0Hung-Yang Chang1Jui-Hsing Chang2Jui-Hsing Chang3Hsin Chi4Hsin Chi5Chyong-Hsin Hsu6Chia-Ying Lin7Wai-Tim Jim8Chun-Chih Peng9Chun-Chih Peng10Department of Pediatrics, MacKay Children's Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, Taipei, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, Taipei, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, Taipei, TaiwanDepartment of Pediatrics, MacKay Children's Hospital, Taipei, TaiwanDepartment of Medicine, MacKay Medical College, New Taipei City, TaiwanBackground: Survivors of preterm birth are at risk of long-term respiratory consequences. The objective of this prospective study was to assess pulmonary function at preschool age of former very low birth weight (VLBW) preterm children.Methods: Lung function of children born preterm and term controls aged 5–6 years were assessed by spirometry. The results were converted to z-scores. A questionnaire regarding respiratory symptoms was completed. Associations to gestational age (GA), birth weight (BW), bronchopulmonary dysplasia (BPD), and perinatal factors were assessed.Results: In total, 85 VLBW preterm children and 29 term controls were studied. Of the preterm children, the mean GA was 28.6 ± 2.6 weeks and the mean BW was 1,047 ± 273 gm. Preterm children had significantly lower z-scores of forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC) ratio, and forced expiratory flow rate between 25–75% of FVC (FEF25−75), compared with term controls (−0.73 vs. 0.04, p = 0.002; −0.22 vs. 0.39, p = 0.003; −0.93 vs. 0.0, p < 0.001; respectively). Further segregation of the preterm group revealed significantly impaired FEV1, FEF25−75 in children at earlier gestation (≤ 28 weeks, n = 45), lighter at birth (≤ 1,000 g, n = 38), or with BPD (n = 55) compared with term controls (p < 0.05). There were significant negative relationships between the severity of BPD with FEV1, FVC, and FEF25−75 (p < 0.05). However, no correlation between lung function measurements and respiratory symptoms was found.Conclusions: VLBW preterm infants have reduced lung function at preschool age, especially among those with younger GA, lower BW, and BPD. Additional long-term follow-up of respiratory outcomes are needed for this vulnerable population.https://www.frontiersin.org/article/10.3389/fped.2020.577673/fullprematuritylung functionbronchopulmonary dysplasiaspirometryvery low birth weight |
| spellingShingle | Hung-Yang Chang Hung-Yang Chang Jui-Hsing Chang Jui-Hsing Chang Hsin Chi Hsin Chi Chyong-Hsin Hsu Chia-Ying Lin Wai-Tim Jim Chun-Chih Peng Chun-Chih Peng Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants Frontiers in Pediatrics prematurity lung function bronchopulmonary dysplasia spirometry very low birth weight |
| title | Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants |
| title_full | Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants |
| title_fullStr | Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants |
| title_full_unstemmed | Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants |
| title_short | Reduced Lung Function at Preschool Age in Survivors of Very Low Birth Weight Preterm Infants |
| title_sort | reduced lung function at preschool age in survivors of very low birth weight preterm infants |
| topic | prematurity lung function bronchopulmonary dysplasia spirometry very low birth weight |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.577673/full |
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