Structural and thermodynamic analyses of the β-to-α transformation in RfaH reveal principles of fold-switching proteins
The two-domain protein RfaH, a paralog of the universally conserved NusG/Spt5 transcription factors, is regulated by autoinhibition coupled to the reversible conformational switch of its 60-residue C-terminal Kyrpides, Ouzounis, Woese (KOW) domain between an α-hairpin and a β-barrel. In contrast, Nu...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/76630 |