ASSESSMENT OF RELATED ANAMNESTIC AND CLINICAL FACTORS ON EFFICACY AND SAFETY OF ANTI-HELICOBACTER PYLORI THERAPY
The article presents the results of a prospective clinical study in which 100 patients with H. pylori-associated peptic ulcer disease of stomach/duodenum were examined. The aim of the study was to assess the effect of concomitant anamnestic and clinical factors on the efficacy and safety of eradicat...
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| Format: | Article |
| Language: | Russian |
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SINAPS LLC
2016-03-01
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| Series: | Архивъ внутренней медицины |
| Subjects: | |
| Online Access: | https://www.medarhive.ru/jour/article/view/487 |
| _version_ | 1826558758491258880 |
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| author | D. N. Andreev I. V. Maev Yu. A. Kucheryavyy D. T. Dicheva |
| author_facet | D. N. Andreev I. V. Maev Yu. A. Kucheryavyy D. T. Dicheva |
| author_sort | D. N. Andreev |
| collection | DOAJ |
| description | The article presents the results of a prospective clinical study in which 100 patients with H. pylori-associated peptic ulcer disease of stomach/duodenum were examined. The aim of the study was to assess the effect of concomitant anamnestic and clinical factors on the efficacy and safety of eradication therapy (ET). Type 2 diabetes mellitus is a factor that significantly reduces the efficiency of ET with OR 0.21 (95% CI 0,06-0,69, p = 0,0102). Using a macrolide antibiotics prior to ET during the previous 12 months is associated with a reduction in the effectiveness of H. pylori eradication with OR 0.27 (95% CI 0,08-0,90, p = 0,0342). Despite the lack of statistical significance observed negative effect on the efficiency of ET factors such as smoking and increased BMI. Smoking, female gender, age over 50 years and the presence of type 2 diabetes mellitus had no significant impact on the safety profile of ET. |
| first_indexed | 2024-04-10T03:56:54Z |
| format | Article |
| id | doaj.art-1f4853bf9eb24a19be506c1ff26a8cb1 |
| institution | Directory Open Access Journal |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| last_indexed | 2025-03-14T08:49:35Z |
| publishDate | 2016-03-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj.art-1f4853bf9eb24a19be506c1ff26a8cb12025-03-02T12:48:57ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642016-03-0161293310.20514/2226-6704-2016-6-1-29-33491ASSESSMENT OF RELATED ANAMNESTIC AND CLINICAL FACTORS ON EFFICACY AND SAFETY OF ANTI-HELICOBACTER PYLORI THERAPYD. N. Andreev0I. V. Maev1Yu. A. Kucheryavyy2D. T. Dicheva3Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, RussiaMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, RussiaMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, RussiaMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, Moscow, RussiaThe article presents the results of a prospective clinical study in which 100 patients with H. pylori-associated peptic ulcer disease of stomach/duodenum were examined. The aim of the study was to assess the effect of concomitant anamnestic and clinical factors on the efficacy and safety of eradication therapy (ET). Type 2 diabetes mellitus is a factor that significantly reduces the efficiency of ET with OR 0.21 (95% CI 0,06-0,69, p = 0,0102). Using a macrolide antibiotics prior to ET during the previous 12 months is associated with a reduction in the effectiveness of H. pylori eradication with OR 0.27 (95% CI 0,08-0,90, p = 0,0342). Despite the lack of statistical significance observed negative effect on the efficiency of ET factors such as smoking and increased BMI. Smoking, female gender, age over 50 years and the presence of type 2 diabetes mellitus had no significant impact on the safety profile of ET.https://www.medarhive.ru/jour/article/view/487helicobacter pyloripeptic ulceranti-helicobacter pylori therapyeradication therapysafetyside effects |
| spellingShingle | D. N. Andreev I. V. Maev Yu. A. Kucheryavyy D. T. Dicheva ASSESSMENT OF RELATED ANAMNESTIC AND CLINICAL FACTORS ON EFFICACY AND SAFETY OF ANTI-HELICOBACTER PYLORI THERAPY Архивъ внутренней медицины helicobacter pylori peptic ulcer anti-helicobacter pylori therapy eradication therapy safety side effects |
| title | ASSESSMENT OF RELATED ANAMNESTIC AND CLINICAL FACTORS ON EFFICACY AND SAFETY OF ANTI-HELICOBACTER PYLORI THERAPY |
| title_full | ASSESSMENT OF RELATED ANAMNESTIC AND CLINICAL FACTORS ON EFFICACY AND SAFETY OF ANTI-HELICOBACTER PYLORI THERAPY |
| title_fullStr | ASSESSMENT OF RELATED ANAMNESTIC AND CLINICAL FACTORS ON EFFICACY AND SAFETY OF ANTI-HELICOBACTER PYLORI THERAPY |
| title_full_unstemmed | ASSESSMENT OF RELATED ANAMNESTIC AND CLINICAL FACTORS ON EFFICACY AND SAFETY OF ANTI-HELICOBACTER PYLORI THERAPY |
| title_short | ASSESSMENT OF RELATED ANAMNESTIC AND CLINICAL FACTORS ON EFFICACY AND SAFETY OF ANTI-HELICOBACTER PYLORI THERAPY |
| title_sort | assessment of related anamnestic and clinical factors on efficacy and safety of anti helicobacter pylori therapy |
| topic | helicobacter pylori peptic ulcer anti-helicobacter pylori therapy eradication therapy safety side effects |
| url | https://www.medarhive.ru/jour/article/view/487 |
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