Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects
Objective: Evidence of oxidative stress was reported in individuals with Down syndrome. There is a growing interest in the contribution of the immune system in Down syndrome. The aim of this study is to evaluate the coenzyme Q10 and selected pro-inflammatory markers such as interleukin 6 and tumor n...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2017-01-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S225555361630129X |
| _version_ | 1811255210728751104 |
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| author | Moushira E. Zaki Hala T. El-Bassyouni Angie M.S. Tosson Eman Youness Jihan Hussein |
| author_facet | Moushira E. Zaki Hala T. El-Bassyouni Angie M.S. Tosson Eman Youness Jihan Hussein |
| author_sort | Moushira E. Zaki |
| collection | DOAJ |
| description | Objective: Evidence of oxidative stress was reported in individuals with Down syndrome. There is a growing interest in the contribution of the immune system in Down syndrome. The aim of this study is to evaluate the coenzyme Q10 and selected pro-inflammatory markers such as interleukin 6 and tumor necrosis factor α in children with Down syndrome.
Methods: Eighty-six children (5–8 years of age) were enrolled in this case-control study from two public institutions. At the time of sampling, the patients and controls suffered from no acute or chronic illnesses and received no therapies or supplements. The levels of interleukin 6, tumor necrosis factor α, coenzyme Q10, fasting blood glucose, and intelligence quotient were measured.
Results: Forty-three young Down syndrome children and forty-three controls were included over a period of eight months (January–August 2014). Compared with the control group, the Down syndrome patients showed significant increase in interleukin 6 and tumor necrosis factor α (p = 0.002), while coenzyme Q10 was significantly decreased (p = 0.002). Also, body mass index and fasting blood glucose were significantly increased in patients. There was a significantly positive correlation between coenzyme Q10 and intelligence quotient levels, as well as between interleukin 6 and tumor necrosis factor α.
Conclusion: Interleukin 6 and tumor necrosis factor α levels in young children with Down syndrome may be used as biomarkers reflecting the neurodegenerative process in them. Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms. |
| first_indexed | 2024-04-12T17:20:23Z |
| format | Article |
| id | doaj.art-1f4a8c808b1d48dd92f22d2d8ae4b72b |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T17:20:23Z |
| publishDate | 2017-01-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-1f4a8c808b1d48dd92f22d2d8ae4b72b2022-12-22T03:23:29ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362017-01-0193110010410.1016/j.jpedp.2016.04.007Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspectsMoushira E. Zaki0Hala T. El-Bassyouni1Angie M.S. Tosson2Eman Youness3Jihan Hussein4National Research Centre, Medical Research Division, Biological Anthropology Department, Cairo, EgitoNational Research Centre, Human Genetics and Genome Research Division, Clinical Genetics Department, Cairo, EgitoCairo University, Faculty of Medicine, Pediatrics Department, Cairo, EgitoNational Research Centre, Medical Research Division, Medical Biochemistry Department, Cairo, EgitoNational Research Centre, Medical Research Division, Medical Biochemistry Department, Cairo, EgitoObjective: Evidence of oxidative stress was reported in individuals with Down syndrome. There is a growing interest in the contribution of the immune system in Down syndrome. The aim of this study is to evaluate the coenzyme Q10 and selected pro-inflammatory markers such as interleukin 6 and tumor necrosis factor α in children with Down syndrome. Methods: Eighty-six children (5–8 years of age) were enrolled in this case-control study from two public institutions. At the time of sampling, the patients and controls suffered from no acute or chronic illnesses and received no therapies or supplements. The levels of interleukin 6, tumor necrosis factor α, coenzyme Q10, fasting blood glucose, and intelligence quotient were measured. Results: Forty-three young Down syndrome children and forty-three controls were included over a period of eight months (January–August 2014). Compared with the control group, the Down syndrome patients showed significant increase in interleukin 6 and tumor necrosis factor α (p = 0.002), while coenzyme Q10 was significantly decreased (p = 0.002). Also, body mass index and fasting blood glucose were significantly increased in patients. There was a significantly positive correlation between coenzyme Q10 and intelligence quotient levels, as well as between interleukin 6 and tumor necrosis factor α. Conclusion: Interleukin 6 and tumor necrosis factor α levels in young children with Down syndrome may be used as biomarkers reflecting the neurodegenerative process in them. Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms.http://www.sciencedirect.com/science/article/pii/S225555361630129XCoenzyme Q10Down syndrome childrenInterleukin 6Oxidative stressTumor necrosis factor α |
| spellingShingle | Moushira E. Zaki Hala T. El-Bassyouni Angie M.S. Tosson Eman Youness Jihan Hussein Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects Jornal de Pediatria (Versão em Português) Coenzyme Q10 Down syndrome children Interleukin 6 Oxidative stress Tumor necrosis factor α |
| title | Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects |
| title_full | Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects |
| title_fullStr | Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects |
| title_full_unstemmed | Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects |
| title_short | Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects |
| title_sort | coenzyme q10 and pro inflammatory markers in children with down syndrome clinical and biochemical aspects |
| topic | Coenzyme Q10 Down syndrome children Interleukin 6 Oxidative stress Tumor necrosis factor α |
| url | http://www.sciencedirect.com/science/article/pii/S225555361630129X |
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