Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk
Abstract Cancer is the main cause of death worldwide and metastasis is a major cause of poor prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a multiplex process, including EMT through cytoskeleton remodeling and interaction with TME. Tens of thousands of putative...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13046-023-02741-x |
| _version_ | 1797773866985062400 |
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| author | Mohammad Ahmad Louis-Bastien Weiswald Laurent Poulain Christophe Denoyelle Matthieu Meryet-Figuiere |
| author_facet | Mohammad Ahmad Louis-Bastien Weiswald Laurent Poulain Christophe Denoyelle Matthieu Meryet-Figuiere |
| author_sort | Mohammad Ahmad |
| collection | DOAJ |
| description | Abstract Cancer is the main cause of death worldwide and metastasis is a major cause of poor prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a multiplex process, including EMT through cytoskeleton remodeling and interaction with TME. Tens of thousands of putative lncRNAs have been identified, but the biological functions of most are still to be identified. However, lncRNAs have already emerged as key regulators of gene expression at transcriptional and post-transcriptional level to control gene expression in a spatio-temporal fashion. LncRNA-dependent mechanisms can control cell fates during development and their perturbed expression is associated with the onset and progression of many diseases including cancer. LncRNAs have been involved in each step of cancer cells metastasis through different modes of action. The investigation of lncRNAs different roles in cancer metastasis could possibly lead to the identification of new biomarkers and innovative cancer therapeutic options. |
| first_indexed | 2024-03-12T22:12:13Z |
| format | Article |
| id | doaj.art-1f4c2771b6a3420a838dd514d0c3ae53 |
| institution | Directory Open Access Journal |
| issn | 1756-9966 |
| language | English |
| last_indexed | 2024-03-12T22:12:13Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj.art-1f4c2771b6a3420a838dd514d0c3ae532023-07-23T11:29:47ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662023-07-0142111410.1186/s13046-023-02741-xInvolvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalkMohammad Ahmad0Louis-Bastien Weiswald1Laurent Poulain2Christophe Denoyelle3Matthieu Meryet-Figuiere4(Interdisciplinary Research Unit for Cancer Prevention and Treatment), Baclesse Cancer Centre, Université de Caen Normandie Inserm Anticipe UMR 1086, Normandie Univ(Interdisciplinary Research Unit for Cancer Prevention and Treatment), Baclesse Cancer Centre, Université de Caen Normandie Inserm Anticipe UMR 1086, Normandie Univ(Interdisciplinary Research Unit for Cancer Prevention and Treatment), Baclesse Cancer Centre, Université de Caen Normandie Inserm Anticipe UMR 1086, Normandie Univ(Interdisciplinary Research Unit for Cancer Prevention and Treatment), Baclesse Cancer Centre, Université de Caen Normandie Inserm Anticipe UMR 1086, Normandie Univ(Interdisciplinary Research Unit for Cancer Prevention and Treatment), Baclesse Cancer Centre, Université de Caen Normandie Inserm Anticipe UMR 1086, Normandie UnivAbstract Cancer is the main cause of death worldwide and metastasis is a major cause of poor prognosis and cancer-associated mortality. Metastatic conversion of cancer cells is a multiplex process, including EMT through cytoskeleton remodeling and interaction with TME. Tens of thousands of putative lncRNAs have been identified, but the biological functions of most are still to be identified. However, lncRNAs have already emerged as key regulators of gene expression at transcriptional and post-transcriptional level to control gene expression in a spatio-temporal fashion. LncRNA-dependent mechanisms can control cell fates during development and their perturbed expression is associated with the onset and progression of many diseases including cancer. LncRNAs have been involved in each step of cancer cells metastasis through different modes of action. The investigation of lncRNAs different roles in cancer metastasis could possibly lead to the identification of new biomarkers and innovative cancer therapeutic options.https://doi.org/10.1186/s13046-023-02741-xLong non-coding RNAsCancer metastasisEMTCytoskeleton remodelingFunctional screeningRNA-based therapeutics |
| spellingShingle | Mohammad Ahmad Louis-Bastien Weiswald Laurent Poulain Christophe Denoyelle Matthieu Meryet-Figuiere Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk Journal of Experimental & Clinical Cancer Research Long non-coding RNAs Cancer metastasis EMT Cytoskeleton remodeling Functional screening RNA-based therapeutics |
| title | Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk |
| title_full | Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk |
| title_fullStr | Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk |
| title_full_unstemmed | Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk |
| title_short | Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk |
| title_sort | involvement of lncrnas in cancer cells migration invasion and metastasis cytoskeleton and ecm crosstalk |
| topic | Long non-coding RNAs Cancer metastasis EMT Cytoskeleton remodeling Functional screening RNA-based therapeutics |
| url | https://doi.org/10.1186/s13046-023-02741-x |
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