Extrapolating the Coffee and Caffeine (1,3,7-Trimethylxanthine) Effects on Exercise and Metabolism—A Concise Review
The consumption of coffee and caffeine (1,3,7-trimethylxanthine) is part of many cultures worldwide. Their properties include serving as a neurostimulant aid, enhancing energy substrate levels, and improving general exercise performance. Both present therapeutic effects that can also be used to cont...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/24/5031 |
| _version_ | 1797379760876158976 |
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| author | Bernardo Starling-Soares Marcela Pereira Guilherme Renke |
| author_facet | Bernardo Starling-Soares Marcela Pereira Guilherme Renke |
| author_sort | Bernardo Starling-Soares |
| collection | DOAJ |
| description | The consumption of coffee and caffeine (1,3,7-trimethylxanthine) is part of many cultures worldwide. Their properties include serving as a neurostimulant aid, enhancing energy substrate levels, and improving general exercise performance. Both present therapeutic effects that can also be used to control chronic and metabolic diseases due to four mechanisms: adenosine receptor antagonism, increased catecholamine concentrations, a phosphodiesterase inhibitor, and a stimulator of calcium-release channels. Despite the individual genetic variabilities, distinct mechanisms have been demonstrated to improve physical performance, thermogenesis, lipolysis, insulin sensitivity, and hormonal modulation. Thus, coffee consumption and caffeine supplementation may enhance physical and mental performance and may improve metabolic variables, reducing oxidative stress, inflammation, and insulin resistance. Current data reveal vital aspects of coffee and caffeine consumption in specific populations, although further studies are needed to define clinical interventions with caffeine in obesity and chronic conditions. |
| first_indexed | 2024-03-08T20:27:42Z |
| format | Article |
| id | doaj.art-1f4fb17f51bb472eaad9f628648755ef |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T20:27:42Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1f4fb17f51bb472eaad9f628648755ef2023-12-22T14:29:53ZengMDPI AGNutrients2072-66432023-12-011524503110.3390/nu15245031Extrapolating the Coffee and Caffeine (1,3,7-Trimethylxanthine) Effects on Exercise and Metabolism—A Concise ReviewBernardo Starling-Soares0Marcela Pereira1Guilherme Renke2Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31310-250, MG, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, RJ, BrazilNutrindo Ideais Performance and Nutrition Research Center, Rio de Janeiro 22411-040, RJ, BrazilThe consumption of coffee and caffeine (1,3,7-trimethylxanthine) is part of many cultures worldwide. Their properties include serving as a neurostimulant aid, enhancing energy substrate levels, and improving general exercise performance. Both present therapeutic effects that can also be used to control chronic and metabolic diseases due to four mechanisms: adenosine receptor antagonism, increased catecholamine concentrations, a phosphodiesterase inhibitor, and a stimulator of calcium-release channels. Despite the individual genetic variabilities, distinct mechanisms have been demonstrated to improve physical performance, thermogenesis, lipolysis, insulin sensitivity, and hormonal modulation. Thus, coffee consumption and caffeine supplementation may enhance physical and mental performance and may improve metabolic variables, reducing oxidative stress, inflammation, and insulin resistance. Current data reveal vital aspects of coffee and caffeine consumption in specific populations, although further studies are needed to define clinical interventions with caffeine in obesity and chronic conditions.https://www.mdpi.com/2072-6643/15/24/5031caffeineinsulin resistanceobesityexercisethermogenic effect |
| spellingShingle | Bernardo Starling-Soares Marcela Pereira Guilherme Renke Extrapolating the Coffee and Caffeine (1,3,7-Trimethylxanthine) Effects on Exercise and Metabolism—A Concise Review Nutrients caffeine insulin resistance obesity exercise thermogenic effect |
| title | Extrapolating the Coffee and Caffeine (1,3,7-Trimethylxanthine) Effects on Exercise and Metabolism—A Concise Review |
| title_full | Extrapolating the Coffee and Caffeine (1,3,7-Trimethylxanthine) Effects on Exercise and Metabolism—A Concise Review |
| title_fullStr | Extrapolating the Coffee and Caffeine (1,3,7-Trimethylxanthine) Effects on Exercise and Metabolism—A Concise Review |
| title_full_unstemmed | Extrapolating the Coffee and Caffeine (1,3,7-Trimethylxanthine) Effects on Exercise and Metabolism—A Concise Review |
| title_short | Extrapolating the Coffee and Caffeine (1,3,7-Trimethylxanthine) Effects on Exercise and Metabolism—A Concise Review |
| title_sort | extrapolating the coffee and caffeine 1 3 7 trimethylxanthine effects on exercise and metabolism a concise review |
| topic | caffeine insulin resistance obesity exercise thermogenic effect |
| url | https://www.mdpi.com/2072-6643/15/24/5031 |
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