Pretreatment Neutrophil-to-Lymphocyte Ratio Associated with Tumor Recurrence and Survival in Patients Achieving a Pathological Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer
The clinical influence of the neutrophil-to-lymphocyte ratio (NLR) in predicting outcomes in patients with locally advanced rectal cancer (LARC) who achieve a pathological complete response (pCR) to neoadjuvant chemoradiotherapy (NACRT) has seldom been investigated. We retrospectively recruited 102...
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MDPI AG
2021-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/18/4589 |
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| author | Chun-Ming Huang Ming-Yii Huang Hsiang-Lin Tsai Ching-Wen Huang Wei-Chih Su Tsung-Kun Chang Yen-Cheng Chen Ching-Chun Li Jaw-Yuan Wang |
| author_facet | Chun-Ming Huang Ming-Yii Huang Hsiang-Lin Tsai Ching-Wen Huang Wei-Chih Su Tsung-Kun Chang Yen-Cheng Chen Ching-Chun Li Jaw-Yuan Wang |
| author_sort | Chun-Ming Huang |
| collection | DOAJ |
| description | The clinical influence of the neutrophil-to-lymphocyte ratio (NLR) in predicting outcomes in patients with locally advanced rectal cancer (LARC) who achieve a pathological complete response (pCR) to neoadjuvant chemoradiotherapy (NACRT) has seldom been investigated. We retrospectively recruited 102 patients with LARC who achieved a pCR to NACRT and the association of NLR status with survival and tumor recurrence in the patients was analyzed. Thirteen patients (12.7%) developed tumor recurrence. A high NLR (≥3.2) was significantly associated with tumor recurrence (<i>p</i> = 0.039). The 5-year OS rates in patients with a low NLR and patients with a high NLR were 95.1% and 77.7%, respectively (<i>p</i> = 0.014); the 5-year DFS rates in patients with low NLR and patients with a high NLR were 90.6% and 71.3%, respectively (<i>p</i> = 0.031). The Cox proportional hazards model indicated that an NLR of ≥3.2 was an independent poor prognostic factor for DFS (hazard ratio [HR] = 3.12, 95% confidence interval [CI] = 1.06–9.46, <i>p</i> = 0.048) and OS (HR = 6.96, 95% CI = 1.53–35.51, <i>p</i> = 0.013). A pretreatment high NLR (≥3.2) was a promising predictor of reduced OS and DFS in patients with LARC who achieved a pCR to NACRT. |
| first_indexed | 2024-03-10T07:50:03Z |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:50:03Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1f50b34ba0fc4f8e917068ccb72c1a012023-11-22T12:17:32ZengMDPI AGCancers2072-66942021-09-011318458910.3390/cancers13184589Pretreatment Neutrophil-to-Lymphocyte Ratio Associated with Tumor Recurrence and Survival in Patients Achieving a Pathological Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal CancerChun-Ming Huang0Ming-Yii Huang1Hsiang-Lin Tsai2Ching-Wen Huang3Wei-Chih Su4Tsung-Kun Chang5Yen-Cheng Chen6Ching-Chun Li7Jaw-Yuan Wang8Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80708, TaiwanDepartment of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung 80708, TaiwanDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanThe clinical influence of the neutrophil-to-lymphocyte ratio (NLR) in predicting outcomes in patients with locally advanced rectal cancer (LARC) who achieve a pathological complete response (pCR) to neoadjuvant chemoradiotherapy (NACRT) has seldom been investigated. We retrospectively recruited 102 patients with LARC who achieved a pCR to NACRT and the association of NLR status with survival and tumor recurrence in the patients was analyzed. Thirteen patients (12.7%) developed tumor recurrence. A high NLR (≥3.2) was significantly associated with tumor recurrence (<i>p</i> = 0.039). The 5-year OS rates in patients with a low NLR and patients with a high NLR were 95.1% and 77.7%, respectively (<i>p</i> = 0.014); the 5-year DFS rates in patients with low NLR and patients with a high NLR were 90.6% and 71.3%, respectively (<i>p</i> = 0.031). The Cox proportional hazards model indicated that an NLR of ≥3.2 was an independent poor prognostic factor for DFS (hazard ratio [HR] = 3.12, 95% confidence interval [CI] = 1.06–9.46, <i>p</i> = 0.048) and OS (HR = 6.96, 95% CI = 1.53–35.51, <i>p</i> = 0.013). A pretreatment high NLR (≥3.2) was a promising predictor of reduced OS and DFS in patients with LARC who achieved a pCR to NACRT.https://www.mdpi.com/2072-6694/13/18/4589locally advanced rectal cancerneoadjuvant chemoradiotherapyneutrophil-to-lymphocyte ratioprognostic factorpathological complete response |
| spellingShingle | Chun-Ming Huang Ming-Yii Huang Hsiang-Lin Tsai Ching-Wen Huang Wei-Chih Su Tsung-Kun Chang Yen-Cheng Chen Ching-Chun Li Jaw-Yuan Wang Pretreatment Neutrophil-to-Lymphocyte Ratio Associated with Tumor Recurrence and Survival in Patients Achieving a Pathological Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer Cancers locally advanced rectal cancer neoadjuvant chemoradiotherapy neutrophil-to-lymphocyte ratio prognostic factor pathological complete response |
| title | Pretreatment Neutrophil-to-Lymphocyte Ratio Associated with Tumor Recurrence and Survival in Patients Achieving a Pathological Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer |
| title_full | Pretreatment Neutrophil-to-Lymphocyte Ratio Associated with Tumor Recurrence and Survival in Patients Achieving a Pathological Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer |
| title_fullStr | Pretreatment Neutrophil-to-Lymphocyte Ratio Associated with Tumor Recurrence and Survival in Patients Achieving a Pathological Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer |
| title_full_unstemmed | Pretreatment Neutrophil-to-Lymphocyte Ratio Associated with Tumor Recurrence and Survival in Patients Achieving a Pathological Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer |
| title_short | Pretreatment Neutrophil-to-Lymphocyte Ratio Associated with Tumor Recurrence and Survival in Patients Achieving a Pathological Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer |
| title_sort | pretreatment neutrophil to lymphocyte ratio associated with tumor recurrence and survival in patients achieving a pathological complete response following neoadjuvant chemoradiotherapy for rectal cancer |
| topic | locally advanced rectal cancer neoadjuvant chemoradiotherapy neutrophil-to-lymphocyte ratio prognostic factor pathological complete response |
| url | https://www.mdpi.com/2072-6694/13/18/4589 |
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