Exposing the molecular heterogeneity of glycosylated biotherapeutics

Exposing the molecular heterogeneity of glycosylated biotherapeutics

Abstract The heterogeneity inherent in today’s biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule’s safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment, but existing methods are limited in their ability to a...

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Những tác giả chính: Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas J. Agard, Matthieu Masureel, Joshua Gober, Adel M. ElSohly, Rafael Melani, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Nature Portfolio 2024-04-01
Loạt:Nature Communications
Truy cập trực tuyến:https://doi.org/10.1038/s41467-024-47693-8

Internet

https://doi.org/10.1038/s41467-024-47693-8

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