Next-generation sequencing to characterise pyrazinamide resistance in Mycobacterium tuberculosis isolates from two Balkan countries

Next-generation sequencing to characterise pyrazinamide resistance in Mycobacterium tuberculosis isolates from two Balkan countries

ABSTRACT: Objectives: Next-generation sequencing (NGS) can provide a comprehensive analysis of the genetic alterations most commonly linked with pyrazinamide (PZA) resistance. However, there are no studies reporting the molecular background of PZA resistance in Mycobacterium tuberculosis (TB) isola...

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Bibliographic Details
Main Authors: Eva Sodja, Simon Koren, Nataša Toplak, Sara Truden, Manca Žolnir-Dovč
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Tuberculosis
Mycobacterium tuberculosis
Next-generation sequencing
pncA
Pyrazinamide
Phenotypic drug susceptibility testing
Online Access:http://www.sciencedirect.com/science/article/pii/S221371652100254X

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