An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage
Atorvastatin has been shown to reduce early brain edema and neuronal death after subarachnoid hemorrhage, but its mechanism is not clear. In this study, rat models of subarachnoid hemorrhage were established by autologous blood injection in the cisterna magna. Rat models were intragastrically admini...
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=10;spage=1947;epage=1954;aulast= |
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| author | Jun-Hui Chen Ting Wu Wen-Yuan Xia Zhong-Hua Shi Chun-Lei Zhang Lei Chen Qian-Xue Chen Yu-Hai Wang |
| author_facet | Jun-Hui Chen Ting Wu Wen-Yuan Xia Zhong-Hua Shi Chun-Lei Zhang Lei Chen Qian-Xue Chen Yu-Hai Wang |
| author_sort | Jun-Hui Chen |
| collection | DOAJ |
| description | Atorvastatin has been shown to reduce early brain edema and neuronal death after subarachnoid hemorrhage, but its mechanism is not clear. In this study, rat models of subarachnoid hemorrhage were established by autologous blood injection in the cisterna magna. Rat models were intragastrically administered 20 mg/kg atorvastatin 24 hours before subarachnoid hemorrhage, 12 and 36 hours after subarachnoid hemorrhage. Compared with the controls, atorvastatin treatment demonstrated that at 72 hours after subarachnoid hemorrhage, neurological function had clearly improved; brain edema was remarkably relieved; cell apoptosis was markedly reduced in the cerebral cortex of rats; the number of autophagy-related protein Beclin-1-positive cells and the expression levels of Beclin-1 and LC3 were increased compared with subarachnoid hemorrhage only. The ultrastructural damage of neurons in the temporal lobe was also noticeably alleviated. The similarities between the effects of atorvastatin and rapamycin were seen in all the measured outcomes of subarachnoid hemorrhage. However, these were contrary to the results of 3-methyladenine injection, which inhibits the signaling pathway of autophagy. These findings indicate that atorvastatin plays an early neuroprotective role in subarachnoid hemorrhage by activating autophagy. The experimental protocol was approved by the Animal Ethics Committee of Anhui Medical University, China (904 Hospital of Joint Logistic Support Force of PLA; approval No. YXLL-2017-09) on February 22, 2017. |
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| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-21T20:19:21Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Neural Regeneration Research |
| spelling | doaj.art-1f55513e04434610ac20f08bbc9e625b2022-12-21T18:51:32ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742020-01-0115101947195410.4103/1673-5374.280326An early neuroprotective effect of atorvastatin against subarachnoid hemorrhageJun-Hui ChenTing WuWen-Yuan XiaZhong-Hua ShiChun-Lei ZhangLei ChenQian-Xue ChenYu-Hai WangAtorvastatin has been shown to reduce early brain edema and neuronal death after subarachnoid hemorrhage, but its mechanism is not clear. In this study, rat models of subarachnoid hemorrhage were established by autologous blood injection in the cisterna magna. Rat models were intragastrically administered 20 mg/kg atorvastatin 24 hours before subarachnoid hemorrhage, 12 and 36 hours after subarachnoid hemorrhage. Compared with the controls, atorvastatin treatment demonstrated that at 72 hours after subarachnoid hemorrhage, neurological function had clearly improved; brain edema was remarkably relieved; cell apoptosis was markedly reduced in the cerebral cortex of rats; the number of autophagy-related protein Beclin-1-positive cells and the expression levels of Beclin-1 and LC3 were increased compared with subarachnoid hemorrhage only. The ultrastructural damage of neurons in the temporal lobe was also noticeably alleviated. The similarities between the effects of atorvastatin and rapamycin were seen in all the measured outcomes of subarachnoid hemorrhage. However, these were contrary to the results of 3-methyladenine injection, which inhibits the signaling pathway of autophagy. These findings indicate that atorvastatin plays an early neuroprotective role in subarachnoid hemorrhage by activating autophagy. The experimental protocol was approved by the Animal Ethics Committee of Anhui Medical University, China (904 Hospital of Joint Logistic Support Force of PLA; approval No. YXLL-2017-09) on February 22, 2017.http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=10;spage=1947;epage=1954;aulast=3-methyladenine; apoptosis; atorvastatin; autophagy; early brain injury; lc3; neuroprotection; rapamycin; subarachnoid hemorrhage |
| spellingShingle | Jun-Hui Chen Ting Wu Wen-Yuan Xia Zhong-Hua Shi Chun-Lei Zhang Lei Chen Qian-Xue Chen Yu-Hai Wang An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage Neural Regeneration Research 3-methyladenine; apoptosis; atorvastatin; autophagy; early brain injury; lc3; neuroprotection; rapamycin; subarachnoid hemorrhage |
| title | An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage |
| title_full | An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage |
| title_fullStr | An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage |
| title_full_unstemmed | An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage |
| title_short | An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage |
| title_sort | early neuroprotective effect of atorvastatin against subarachnoid hemorrhage |
| topic | 3-methyladenine; apoptosis; atorvastatin; autophagy; early brain injury; lc3; neuroprotection; rapamycin; subarachnoid hemorrhage |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=10;spage=1947;epage=1954;aulast= |
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