VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
Mitochondria defects caused by mutant huntingtin (mtHtt) have been implicated in Huntington's disease. Here authors show that VCP binds to mtHtt on the mitochondria, and that treatment with a peptide that disrupts this interaction reduces the cellular and behavioural deficits in mouse models of...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12646 |
| _version_ | 1818342073404751872 |
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| author | Xing Guo XiaoYan Sun Di Hu Ya-Juan Wang Hisashi Fujioka Rajan Vyas Sudha Chakrapani Amit Umesh Joshi Yu Luo Daria Mochly-Rosen Xin Qi |
| author_facet | Xing Guo XiaoYan Sun Di Hu Ya-Juan Wang Hisashi Fujioka Rajan Vyas Sudha Chakrapani Amit Umesh Joshi Yu Luo Daria Mochly-Rosen Xin Qi |
| author_sort | Xing Guo |
| collection | DOAJ |
| description | Mitochondria defects caused by mutant huntingtin (mtHtt) have been implicated in Huntington's disease. Here authors show that VCP binds to mtHtt on the mitochondria, and that treatment with a peptide that disrupts this interaction reduces the cellular and behavioural deficits in mouse models of HD. |
| first_indexed | 2024-12-13T16:08:53Z |
| format | Article |
| id | doaj.art-1f55ff619f9e46718fcb0202f07879be |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:08:53Z |
| publishDate | 2016-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1f55ff619f9e46718fcb0202f07879be2022-12-21T23:38:59ZengNature PortfolioNature Communications2041-17232016-08-017111710.1038/ncomms12646VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s diseaseXing Guo0XiaoYan Sun1Di Hu2Ya-Juan Wang3Hisashi Fujioka4Rajan Vyas5Sudha Chakrapani6Amit Umesh Joshi7Yu Luo8Daria Mochly-Rosen9Xin Qi10Department of Physiology & Biophysics, Case Western Reserve University School of MedicineDepartment of Physiology & Biophysics, Case Western Reserve University School of MedicineDepartment of Physiology & Biophysics, Case Western Reserve University School of MedicineCenter for Proteomics and Bioinformatics, Case Western Reserve University School of MedicineDepartment of Pharmacology, Case Western Reserve University School of MedicineDepartment of Physiology & Biophysics, Case Western Reserve University School of MedicineDepartment of Physiology & Biophysics, Case Western Reserve University School of MedicineDepartment of Chemical and Systems Biology, Stanford University School of MedicineDepartment of Neurosurgery, Case Western Reserve University School of MedicineDepartment of Chemical and Systems Biology, Stanford University School of MedicineDepartment of Physiology & Biophysics, Case Western Reserve University School of MedicineMitochondria defects caused by mutant huntingtin (mtHtt) have been implicated in Huntington's disease. Here authors show that VCP binds to mtHtt on the mitochondria, and that treatment with a peptide that disrupts this interaction reduces the cellular and behavioural deficits in mouse models of HD.https://doi.org/10.1038/ncomms12646 |
| spellingShingle | Xing Guo XiaoYan Sun Di Hu Ya-Juan Wang Hisashi Fujioka Rajan Vyas Sudha Chakrapani Amit Umesh Joshi Yu Luo Daria Mochly-Rosen Xin Qi VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease Nature Communications |
| title | VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease |
| title_full | VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease |
| title_fullStr | VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease |
| title_full_unstemmed | VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease |
| title_short | VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease |
| title_sort | vcp recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of huntington s disease |
| url | https://doi.org/10.1038/ncomms12646 |
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