Pulmonary Fibrosis Induced by CdSe Nanorods and the Therapy with Modified Procyanidinere
The CdSe nanorod as a one-dimensional nanostructure has an excellent performance in many fields, such as healthcare, new energy, and environmental protection. Thus, it is crucial to investigate its potential adverse health effects prior to their wide exposure. The lung tissue would be the main targe...
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MDPI AG
2022-11-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/10/11/673 |
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| author | Zongkai Yue Ruiren Zhou Qingzhao Li Shaohu Ouyang Lu Liu Qixing Zhou |
| author_facet | Zongkai Yue Ruiren Zhou Qingzhao Li Shaohu Ouyang Lu Liu Qixing Zhou |
| author_sort | Zongkai Yue |
| collection | DOAJ |
| description | The CdSe nanorod as a one-dimensional nanostructure has an excellent performance in many fields, such as healthcare, new energy, and environmental protection. Thus, it is crucial to investigate its potential adverse health effects prior to their wide exposure. The lung tissue would be the main target organ after CdSe nanorods enter living systems. Here, we showed that pulmonary instillation of CdSe nanorods could decrease the vitality of T-SOD and T-AOC in lung tissues of a rat, increase MDA and hydroxyproline levels and lipid peroxidation products, induce mitochondrial cristae breakage and vacuolization, cause inflammatory responses, and finally induce pulmonary fibrosis. The oral administration of modified procyanidinere could significantly increase the content of antioxidant enzymes, scavenge free radicals, reduce lipid peroxidation, and have protective effects on CdSe nanorods-induced pulmonary fibrosis. The benefit is not only in the early inflammatory stage but also in the later stages of the CdSe nanorods-induced pulmonary fibrosis. |
| first_indexed | 2024-03-09T18:34:57Z |
| format | Article |
| id | doaj.art-1f568f3f87f94497ab8a5b9a42f2c66f |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-09T18:34:57Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-1f568f3f87f94497ab8a5b9a42f2c66f2023-11-24T07:10:04ZengMDPI AGToxics2305-63042022-11-01101167310.3390/toxics10110673Pulmonary Fibrosis Induced by CdSe Nanorods and the Therapy with Modified ProcyanidinereZongkai Yue0Ruiren Zhou1Qingzhao Li2Shaohu Ouyang3Lu Liu4Qixing Zhou5Laboratory of Environmental Protection in Water Transport Engineering, Tianjin Research Institute for Water Transport Engineering, Ministry of Transport of the People’s Republic of China, Tianjin 300456, ChinaDepartment of Biological and Agricultural Engineering, Texas A&M University, College Station, TX 77843-2117, USAPreventive Medicine Department and Department of Biological Science, Hebei United University, Tangshan 063000, ChinaMinistry of Education Key Laboratory of Pollution Processes and Environmental Criteria/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, ChinaMinistry of Education Key Laboratory of Pollution Processes and Environmental Criteria/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, ChinaMinistry of Education Key Laboratory of Pollution Processes and Environmental Criteria/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, ChinaThe CdSe nanorod as a one-dimensional nanostructure has an excellent performance in many fields, such as healthcare, new energy, and environmental protection. Thus, it is crucial to investigate its potential adverse health effects prior to their wide exposure. The lung tissue would be the main target organ after CdSe nanorods enter living systems. Here, we showed that pulmonary instillation of CdSe nanorods could decrease the vitality of T-SOD and T-AOC in lung tissues of a rat, increase MDA and hydroxyproline levels and lipid peroxidation products, induce mitochondrial cristae breakage and vacuolization, cause inflammatory responses, and finally induce pulmonary fibrosis. The oral administration of modified procyanidinere could significantly increase the content of antioxidant enzymes, scavenge free radicals, reduce lipid peroxidation, and have protective effects on CdSe nanorods-induced pulmonary fibrosis. The benefit is not only in the early inflammatory stage but also in the later stages of the CdSe nanorods-induced pulmonary fibrosis.https://www.mdpi.com/2305-6304/10/11/673pulmonary fibrosisCdSe nanorodoral administrationnanotoxicologyprocyanidinere therapy |
| spellingShingle | Zongkai Yue Ruiren Zhou Qingzhao Li Shaohu Ouyang Lu Liu Qixing Zhou Pulmonary Fibrosis Induced by CdSe Nanorods and the Therapy with Modified Procyanidinere Toxics pulmonary fibrosis CdSe nanorod oral administration nanotoxicology procyanidinere therapy |
| title | Pulmonary Fibrosis Induced by CdSe Nanorods and the Therapy with Modified Procyanidinere |
| title_full | Pulmonary Fibrosis Induced by CdSe Nanorods and the Therapy with Modified Procyanidinere |
| title_fullStr | Pulmonary Fibrosis Induced by CdSe Nanorods and the Therapy with Modified Procyanidinere |
| title_full_unstemmed | Pulmonary Fibrosis Induced by CdSe Nanorods and the Therapy with Modified Procyanidinere |
| title_short | Pulmonary Fibrosis Induced by CdSe Nanorods and the Therapy with Modified Procyanidinere |
| title_sort | pulmonary fibrosis induced by cdse nanorods and the therapy with modified procyanidinere |
| topic | pulmonary fibrosis CdSe nanorod oral administration nanotoxicology procyanidinere therapy |
| url | https://www.mdpi.com/2305-6304/10/11/673 |
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