Characteristics of metabolic factors related to arterial stiffness in young and old adults
It has not been adequately studied which biomarkers for cardiovascular risk indicate changes of atherosclerosis by aging process. The current study aimed to investigate the characteristics of metabolic factors related to arterial stiffness in young and old adults. Our cross-sectional study enrolled...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-04-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | http://dx.doi.org/10.1080/10641963.2019.1619754 |
| _version_ | 1797681357230440448 |
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| author | Bo Youn Won Seung Geon Park Soo-Hyun Lee Moon-Jong Kim Hyejin Chun Doohee Hong Young-Sang Kim |
| author_facet | Bo Youn Won Seung Geon Park Soo-Hyun Lee Moon-Jong Kim Hyejin Chun Doohee Hong Young-Sang Kim |
| author_sort | Bo Youn Won |
| collection | DOAJ |
| description | It has not been adequately studied which biomarkers for cardiovascular risk indicate changes of atherosclerosis by aging process. The current study aimed to investigate the characteristics of metabolic factors related to arterial stiffness in young and old adults. Our cross-sectional study enrolled 851 healthy young adults and 719 old adults. Metabolic biomarkers included glucose, lipid profiles, and liver enzymes. In young adults, additional biomarkers such as C-reactive protein, apolipoproteins, lipoprotein(a), ferritin, and 25-hydroxycholecalciferol were measured. Arterial stiffness was evaluated by measuring brachial-ankle pulse wave velocity (baPWV). The mean age was 37.8 and 65.1 years old in the young and old groups, respectively. Without adjustment, most parameters were significantly correlated with baPWV in both young and old groups. Mean baPWV was significantly different according to metabolic syndrome (MetS) in both groups (13.1 and 12.1 m/s in the young subjects with and without MetS, respectively; 17.4 and 15.8 m/s, respectively, in the old group). After adjusting for age, sex, and hemodynamic factors, the difference in baPWV according to MetS was significant only in the old group. The relationship between most biomarkers and baPWV was influenced by metabolic disorders such as hypertension and diabetes in old adults. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and apolipoprotein B were significant in young group. In conclusion, the metabolic biomarkers related to arterial stiffness were different between young and old adults. Contrary to old adults, TC, LDLC, and apolipoprotein B were independent biomarkers for arterial stiffness in healthy young adults. |
| first_indexed | 2024-03-11T23:43:42Z |
| format | Article |
| id | doaj.art-1f58655b0a0b444eaa6fe54670869784 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:42Z |
| publishDate | 2020-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-1f58655b0a0b444eaa6fe546708697842023-09-19T15:19:28ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062020-04-0142322523210.1080/10641963.2019.16197541619754Characteristics of metabolic factors related to arterial stiffness in young and old adultsBo Youn Won0Seung Geon Park1Soo-Hyun Lee2Moon-Jong Kim3Hyejin Chun4Doohee Hong5Young-Sang Kim6Chaum Medical Checkup Center Samseongdong Branch, CHA UniversityCHA Bundang Medical Centre, CHA UniversityCHA Bundang Medical Centre, CHA UniversityChaum Medical Checkup Center Samseongdong Branch, CHA UniversityCHA Bundang Medical Centre, CHA UniversitySuwon Central HospitalCHA Bundang Medical Centre, CHA UniversityIt has not been adequately studied which biomarkers for cardiovascular risk indicate changes of atherosclerosis by aging process. The current study aimed to investigate the characteristics of metabolic factors related to arterial stiffness in young and old adults. Our cross-sectional study enrolled 851 healthy young adults and 719 old adults. Metabolic biomarkers included glucose, lipid profiles, and liver enzymes. In young adults, additional biomarkers such as C-reactive protein, apolipoproteins, lipoprotein(a), ferritin, and 25-hydroxycholecalciferol were measured. Arterial stiffness was evaluated by measuring brachial-ankle pulse wave velocity (baPWV). The mean age was 37.8 and 65.1 years old in the young and old groups, respectively. Without adjustment, most parameters were significantly correlated with baPWV in both young and old groups. Mean baPWV was significantly different according to metabolic syndrome (MetS) in both groups (13.1 and 12.1 m/s in the young subjects with and without MetS, respectively; 17.4 and 15.8 m/s, respectively, in the old group). After adjusting for age, sex, and hemodynamic factors, the difference in baPWV according to MetS was significant only in the old group. The relationship between most biomarkers and baPWV was influenced by metabolic disorders such as hypertension and diabetes in old adults. Total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and apolipoprotein B were significant in young group. In conclusion, the metabolic biomarkers related to arterial stiffness were different between young and old adults. Contrary to old adults, TC, LDLC, and apolipoprotein B were independent biomarkers for arterial stiffness in healthy young adults.http://dx.doi.org/10.1080/10641963.2019.1619754arterial stiffnesspulse wave velocitymetabolic biomarkerslipoprotein |
| spellingShingle | Bo Youn Won Seung Geon Park Soo-Hyun Lee Moon-Jong Kim Hyejin Chun Doohee Hong Young-Sang Kim Characteristics of metabolic factors related to arterial stiffness in young and old adults Clinical and Experimental Hypertension arterial stiffness pulse wave velocity metabolic biomarkers lipoprotein |
| title | Characteristics of metabolic factors related to arterial stiffness in young and old adults |
| title_full | Characteristics of metabolic factors related to arterial stiffness in young and old adults |
| title_fullStr | Characteristics of metabolic factors related to arterial stiffness in young and old adults |
| title_full_unstemmed | Characteristics of metabolic factors related to arterial stiffness in young and old adults |
| title_short | Characteristics of metabolic factors related to arterial stiffness in young and old adults |
| title_sort | characteristics of metabolic factors related to arterial stiffness in young and old adults |
| topic | arterial stiffness pulse wave velocity metabolic biomarkers lipoprotein |
| url | http://dx.doi.org/10.1080/10641963.2019.1619754 |
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