Endothelial Microparticles in Uremia: Biomarkers and Potential Therapeutic Targets
Endothelial microparticles (EMPs) are vesicles derived from cell membranes, which contain outsourced phosphatidylserine and express adhesion molecules, such as cadherin, intercellular cell adhesion molecule-1 (ICAM-1), E-selectin, and integrins. EMPs are expressed under physiological conditions and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/11/5/267 |
| _version_ | 1811279152020455424 |
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| author | Giane Favretto Regiane Stafim da Cunha Maria Aparecida Dalboni Rodrigo Bueno de Oliveira Fellype de Carvalho Barreto Ziad A. Massy Andréa Emilia Marques Stinghen |
| author_facet | Giane Favretto Regiane Stafim da Cunha Maria Aparecida Dalboni Rodrigo Bueno de Oliveira Fellype de Carvalho Barreto Ziad A. Massy Andréa Emilia Marques Stinghen |
| author_sort | Giane Favretto |
| collection | DOAJ |
| description | Endothelial microparticles (EMPs) are vesicles derived from cell membranes, which contain outsourced phosphatidylserine and express adhesion molecules, such as cadherin, intercellular cell adhesion molecule-1 (ICAM-1), E-selectin, and integrins. EMPs are expressed under physiological conditions and continue circulating in the plasma. However, in pathologic conditions their levels increase, and they assume a pro-inflammatory and pro-coagulant role via interactions with monocytes; these effects are related to the development of atherosclerosis. Chronic kidney dysfunction (CKD) characterizes this dysfunctional scenario through the accumulation of uremic solutes in the circulating plasma, whose toxicity is related to the development of cardiovascular diseases. Therefore, this review aims to discuss the formation of EMPs and their biological effects in the uremic environment. Data from previous research demonstrate that uremic toxins are closely associated with the activation of inflammatory biomarkers, cardiovascular dysfunction processes, and the release of EMPs. The impact of a decrease in circulating EMPs in clinical studies has not yet been evaluated. Thus, whether MPs are biochemical markers and/or therapeutic targets has yet to be established. |
| first_indexed | 2024-04-13T00:49:37Z |
| format | Article |
| id | doaj.art-1f59a22eb98b41699b8a268d98eb025c |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-13T00:49:37Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-1f59a22eb98b41699b8a268d98eb025c2022-12-22T03:09:54ZengMDPI AGToxins2072-66512019-05-0111526710.3390/toxins11050267toxins11050267Endothelial Microparticles in Uremia: Biomarkers and Potential Therapeutic TargetsGiane Favretto0Regiane Stafim da Cunha1Maria Aparecida Dalboni2Rodrigo Bueno de Oliveira3Fellype de Carvalho Barreto4Ziad A. Massy5Andréa Emilia Marques Stinghen6Experimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, BrazilExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, BrazilPost-Graduation in Medicine Department, Universidade Nove de Julho, São Paulo 03155-000, SP, BrazilDivision of Nephrology, Department of Internal Medicine, School of Medical Sciences Universidade de Campinas (UNICAMP), Campinas 13083-887, BrazilExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, BrazilDivision of Nephrology, Ambroise Paré University Hospital, APHP, Boulogne-Billancourt, 92100 Paris, FranceExperimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 81531-980, BrazilEndothelial microparticles (EMPs) are vesicles derived from cell membranes, which contain outsourced phosphatidylserine and express adhesion molecules, such as cadherin, intercellular cell adhesion molecule-1 (ICAM-1), E-selectin, and integrins. EMPs are expressed under physiological conditions and continue circulating in the plasma. However, in pathologic conditions their levels increase, and they assume a pro-inflammatory and pro-coagulant role via interactions with monocytes; these effects are related to the development of atherosclerosis. Chronic kidney dysfunction (CKD) characterizes this dysfunctional scenario through the accumulation of uremic solutes in the circulating plasma, whose toxicity is related to the development of cardiovascular diseases. Therefore, this review aims to discuss the formation of EMPs and their biological effects in the uremic environment. Data from previous research demonstrate that uremic toxins are closely associated with the activation of inflammatory biomarkers, cardiovascular dysfunction processes, and the release of EMPs. The impact of a decrease in circulating EMPs in clinical studies has not yet been evaluated. Thus, whether MPs are biochemical markers and/or therapeutic targets has yet to be established.https://www.mdpi.com/2072-6651/11/5/267Endothelial microparticlescardiovascular diseaseuremia |
| spellingShingle | Giane Favretto Regiane Stafim da Cunha Maria Aparecida Dalboni Rodrigo Bueno de Oliveira Fellype de Carvalho Barreto Ziad A. Massy Andréa Emilia Marques Stinghen Endothelial Microparticles in Uremia: Biomarkers and Potential Therapeutic Targets Toxins Endothelial microparticles cardiovascular disease uremia |
| title | Endothelial Microparticles in Uremia: Biomarkers and Potential Therapeutic Targets |
| title_full | Endothelial Microparticles in Uremia: Biomarkers and Potential Therapeutic Targets |
| title_fullStr | Endothelial Microparticles in Uremia: Biomarkers and Potential Therapeutic Targets |
| title_full_unstemmed | Endothelial Microparticles in Uremia: Biomarkers and Potential Therapeutic Targets |
| title_short | Endothelial Microparticles in Uremia: Biomarkers and Potential Therapeutic Targets |
| title_sort | endothelial microparticles in uremia biomarkers and potential therapeutic targets |
| topic | Endothelial microparticles cardiovascular disease uremia |
| url | https://www.mdpi.com/2072-6651/11/5/267 |
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