Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10

Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiation via downregulating frizzled class receptor 10

Objective: Our aim was to test the hypothesis that fatty acid synthase (FASN) expression contributes to radioresistance of nasopharyngeal carcinoma (NPC) cells and that inhibiting FASN enhances radiosensitivity. Methods: Targeting FASN using epigallocatechin gallate (EGCG) or RNA interference in NPC...

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Bibliographic Details
Main Authors: Jiongyu Chen, Fan Zhang, Xiaosha Ren, Yahui Wang, Wenhe Huang, Jianting Zhang, Yukun Cui
Format: Article
Language:English
Published: China Anti-Cancer Association 2020-08-01
Series:Cancer Biology & Medicine
Subjects:
epigallocatechin gallate
fatty acid synthase
frizzled class receptor 10
nasopharyngeal carcinoma
radioresistance
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/1677

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