Etiological factors of cholestasis in early childhood in Children Welfare Teaching Hospital
Abstract: Background: Neonatal cholestasis is defined as prolonged elevation of the serum level of conjugated bilirubin beyond the first 14 days of life. There are many causes of neonatal cholestasis must be differentiate because early intervention may results in a better outcome like (surgical i...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2019-07-01
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| Series: | مجلة كلية الطب |
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| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/487 |
| _version_ | 1797368367431024640 |
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| author | Mohammad Fadhil Ibraheem |
| author_facet | Mohammad Fadhil Ibraheem |
| author_sort | Mohammad Fadhil Ibraheem |
| collection | DOAJ |
| description | Abstract:
Background: Neonatal cholestasis is defined as prolonged elevation of the serum level of conjugated bilirubin beyond the first 14 days of life. There are many causes of neonatal cholestasis must be differentiate because early intervention may results in a better outcome like (surgical intervention in biliary atresia within 2month from birth). Furthermore, other treatable disorders like (galactosemia) to initiate early effective therapy.
Objective: To determine the causes of early childhood cholestasis in children attending the Children Welfare teaching hospital and to study some of associated factors for early childhood cholestasis.
Patients and method: This is across sectional descriptive study for 48 patients attending the Children welfare teaching hospital in Baghdad for the period from first of November 2015 to fifteenth of January 2016.They were evaluated by thorough history, examination and investigations.
Results: a group of 48 patients were enrolled in this study, showed that (30) 62.5%lived in Baghdad and the remains were referred from other governorates, the mean age of patients was 11.1 months±12.4 SD and females were 20(41.7%) and males were 28(58.3%) of the study group. The results revealed that 11(22.9%) caused by congenital infection, 9(18.8%) of cases were idiopathic in origin, 8(16.7%) caused by biliary atresia, 8(16.7%) of unknown origin, 5(10.4%) caused by sepsis( mainly staphylococcus, streptococcus species , E-coli , aureus), 2(4.2%) caused by Progressive familial intrahepatic cholestasis and 1(2.1%) case was caused by each of the following causes: Alagille syndrome, Choledochal cyst, Galactosemia, hypothyroidism and Tyrosinemia .
Conclusion:
Congenital infections are the most common cause in this study, CMV infection is the most common cause of intrauterine infections, Clay color stool, and high alkaline phosphatase levels found mostly in Biliary Atresia, No method by itself is sufficient to diagnose the cause of neonatal cholestasis. Indeed, diagnosis can only be established using all available methods.
Key word: Cholestasis, children, etiology |
| first_indexed | 2024-03-08T17:31:27Z |
| format | Article |
| id | doaj.art-1f5ce3750ae14c49bc22fdebb58e679b |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:31:27Z |
| publishDate | 2019-07-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-1f5ce3750ae14c49bc22fdebb58e679b2024-01-02T14:46:55ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572019-07-0161110.32007/4876-10Etiological factors of cholestasis in early childhood in Children Welfare Teaching HospitalMohammad Fadhil Ibraheem0Department of pediatrics- college of medicine -university of baghdadAbstract: Background: Neonatal cholestasis is defined as prolonged elevation of the serum level of conjugated bilirubin beyond the first 14 days of life. There are many causes of neonatal cholestasis must be differentiate because early intervention may results in a better outcome like (surgical intervention in biliary atresia within 2month from birth). Furthermore, other treatable disorders like (galactosemia) to initiate early effective therapy. Objective: To determine the causes of early childhood cholestasis in children attending the Children Welfare teaching hospital and to study some of associated factors for early childhood cholestasis. Patients and method: This is across sectional descriptive study for 48 patients attending the Children welfare teaching hospital in Baghdad for the period from first of November 2015 to fifteenth of January 2016.They were evaluated by thorough history, examination and investigations. Results: a group of 48 patients were enrolled in this study, showed that (30) 62.5%lived in Baghdad and the remains were referred from other governorates, the mean age of patients was 11.1 months±12.4 SD and females were 20(41.7%) and males were 28(58.3%) of the study group. The results revealed that 11(22.9%) caused by congenital infection, 9(18.8%) of cases were idiopathic in origin, 8(16.7%) caused by biliary atresia, 8(16.7%) of unknown origin, 5(10.4%) caused by sepsis( mainly staphylococcus, streptococcus species , E-coli , aureus), 2(4.2%) caused by Progressive familial intrahepatic cholestasis and 1(2.1%) case was caused by each of the following causes: Alagille syndrome, Choledochal cyst, Galactosemia, hypothyroidism and Tyrosinemia . Conclusion: Congenital infections are the most common cause in this study, CMV infection is the most common cause of intrauterine infections, Clay color stool, and high alkaline phosphatase levels found mostly in Biliary Atresia, No method by itself is sufficient to diagnose the cause of neonatal cholestasis. Indeed, diagnosis can only be established using all available methods. Key word: Cholestasis, children, etiologyhttp://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/487Key word: Cholestasis, children, etiology |
| spellingShingle | Mohammad Fadhil Ibraheem Etiological factors of cholestasis in early childhood in Children Welfare Teaching Hospital مجلة كلية الطب Key word: Cholestasis, children, etiology |
| title | Etiological factors of cholestasis in early childhood in Children Welfare Teaching Hospital |
| title_full | Etiological factors of cholestasis in early childhood in Children Welfare Teaching Hospital |
| title_fullStr | Etiological factors of cholestasis in early childhood in Children Welfare Teaching Hospital |
| title_full_unstemmed | Etiological factors of cholestasis in early childhood in Children Welfare Teaching Hospital |
| title_short | Etiological factors of cholestasis in early childhood in Children Welfare Teaching Hospital |
| title_sort | etiological factors of cholestasis in early childhood in children welfare teaching hospital |
| topic | Key word: Cholestasis, children, etiology |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/487 |
| work_keys_str_mv | AT mohammadfadhilibraheem etiologicalfactorsofcholestasisinearlychildhoodinchildrenwelfareteachinghospital |