Stability of 3', 5'-o-(tetraisopropyldisiloxane-1,3-diyl)nucleosides in the presence of lewis acids

Stability of 3', 5'-o-(tetraisopropyldisiloxane-1,3-diyl)nucleosides in the presence of lewis acids

Trimethylsilyl trifluoromethanesulfonate catalyzes effective isomerization of 3',5'-O-(tetraisopropyldisiloxane1,3-diyl,TIPDS)nucleosides in 1,2-dicloroethane at 0C into 2',3'-O-TIPDS-derivatives to give 55-90% yields. On the other hand 3',5'-O-TIPDS-nucleosides except...

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Bibliographic Details
Main Authors: I. V. Kulikova, D. A. Muradova, S. N. Mikhailov
Format: Article
Language:Russian
Published: MIREA - Russian Technological University 2008-10-01
Series:Тонкие химические технологии
Subjects:
защитные группы нуклеозидов, изомеризация, 3′,5′-o-(тетраизопропилдисилоксан-1,3-диил)нуклеозиды, триметилсилилтрифторметан-сульфонат.
Online Access:https://www.finechem-mirea.ru/jour/article/view/1538
Description
Summary:Trimethylsilyl trifluoromethanesulfonate catalyzes effective isomerization of 3',5'-O-(tetraisopropyldisiloxane1,3-diyl,TIPDS)nucleosides in 1,2-dicloroethane at 0C into 2',3'-O-TIPDS-derivatives to give 55-90% yields. On the other hand 3',5'-O-TIPDS-nucleosides except for uridine derivative 1a were found to be stable in the in the presence of tin tetrachloride and boron trifluoride etherate
ISSN:2410-6593
2686-7575

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