The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling

The C-terminus of the oncoprotein TGAT is necessary for plasma membrane association and efficient RhoA-mediated signaling

Abstract Background Rho guanine exchange factors (RhoGEFs) control cellular processes such as migration, adhesion and proliferation. Alternative splicing of the RhoGEF Trio produces TGAT. The RhoGEF TGAT is an oncoprotein with constitutive RhoGEF activity. We investigated whether the subcellular loc...

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Bibliographic Details
Main Authors: J. van Unen, D. Botman, T. Yin, Y. I. Wu, M. A. Hink, T. W. J. Gadella, M. Postma, J. Goedhart
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cell Biology
Online Access:http://link.springer.com/article/10.1186/s12860-018-0155-2

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