Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases
Abstract Background Thrombocytopenia is a common laboratory abnormality in dogs, and numerous diseases have been associated with its development. Estimates for the sensitivity and specificity of the degree of reduction of platelet concentration for the diagnosis of primary immune‐mediated thrombocyt...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Veterinary Medicine and Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/vms3.1091 |
| _version_ | 1797776568291950592 |
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| author | Marina Martín‐Ambrosio Francés Mayank Seth Mellora Sharman Danica Pollard Ana Liza Ortiz Rachel Miller Thomas Natsiopoulos David Walker Bryn Jones Joshua Hardwick Barbara Glanemann Andrés Salas Garcia Jessica Bacon Aida Gómez Selgas |
| author_facet | Marina Martín‐Ambrosio Francés Mayank Seth Mellora Sharman Danica Pollard Ana Liza Ortiz Rachel Miller Thomas Natsiopoulos David Walker Bryn Jones Joshua Hardwick Barbara Glanemann Andrés Salas Garcia Jessica Bacon Aida Gómez Selgas |
| author_sort | Marina Martín‐Ambrosio Francés |
| collection | DOAJ |
| description | Abstract Background Thrombocytopenia is a common laboratory abnormality in dogs, and numerous diseases have been associated with its development. Estimates for the sensitivity and specificity of the degree of reduction of platelet concentration for the diagnosis of primary immune‐mediated thrombocytopenia (pITP) have not been reported. Objectives To report the prevalence of different causes of thrombocytopenia in dogs in the United Kingdom and to investigate the utility of platelet concentration to differentiate causes of thrombocytopenia. Methods Medical records of 762 dogs with thrombocytopenia presented to seven referral hospitals from January 2017 to December 2018 were retrospectively reviewed. Cases were assigned into the following categories: pITP, infectious diseases, neoplasia, inflammatory/other immune‐mediated disorders and miscellaneous causes. The prevalence of the different categories was estimated, and platelet concentrations were compared. Receiver‐operating characteristic (ROC) curves were used to investigate the utility of platelet concentration to differentiate between causes of thrombocytopenia. Results The most common disease category associated with thrombocytopenia was neoplasia (27.3%), followed by miscellaneous causes (26.9%), pITP (18.8%), inflammatory/immune‐mediated disorders (14.4%) and infectious diseases (12.6%). Dogs with pITP had significantly lower platelet concentrations (median 8 × 109/L, range: 0–70 × 109/L) than dogs in the other four categories. Platelet concentration was useful for distinguishing pITP from other causes of thrombocytopenia (area under ROC curve = 0.89, 95% confidence interval 0.87, 0.92), with a platelet concentration ≤12 × 109/L being 60% sensitive and 90% specific. Conclusions Severe thrombocytopenia was highly specific for a diagnosis of pITP, which was more prevalent in this UK population of thrombocytopenic dogs compared with previous epidemiological studies. Conversely, the proportion of dogs with infectious diseases was lower than in previous reports from other locations. |
| first_indexed | 2024-03-12T22:51:45Z |
| format | Article |
| id | doaj.art-1f5f9641e54a4be09df77ee6782786d4 |
| institution | Directory Open Access Journal |
| issn | 2053-1095 |
| language | English |
| last_indexed | 2024-03-12T22:51:45Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj.art-1f5f9641e54a4be09df77ee6782786d42023-07-20T08:09:46ZengWileyVeterinary Medicine and Science2053-10952023-07-01941495150710.1002/vms3.1091Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 casesMarina Martín‐Ambrosio Francés0Mayank Seth1Mellora Sharman2Danica Pollard3Ana Liza Ortiz4Rachel Miller5Thomas Natsiopoulos6David Walker7Bryn Jones8Joshua Hardwick9Barbara Glanemann10Andrés Salas Garcia11Jessica Bacon12Aida Gómez Selgas13Animal Health Trust Newmarket Suffolk UKAnimal Health Trust Newmarket Suffolk UKAnimal Health Trust Newmarket Suffolk UKThe British Horse Society Kenilworth Warwickshire UKSchool of Veterinary Medicine and Science University of Nottingham Loughborough UKDick White Referrals Six Mile Bottom Cambridgeshire UKDick White Referrals Six Mile Bottom Cambridgeshire UKAnderson Moores Veterinary Specialists Winchester Hampshire UKAnderson Moores Veterinary Specialists Winchester Hampshire UKLangford Vets, University of Bristol Langford UKQueen Mother Hospital for Animals The Royal Veterinary College Hatfield Hertfordshire UKPride Veterinary Centre Derby UKWear Referrals Veterinary Hospital Stockton‐on‐Tees UKAnimal Health Trust Newmarket Suffolk UKAbstract Background Thrombocytopenia is a common laboratory abnormality in dogs, and numerous diseases have been associated with its development. Estimates for the sensitivity and specificity of the degree of reduction of platelet concentration for the diagnosis of primary immune‐mediated thrombocytopenia (pITP) have not been reported. Objectives To report the prevalence of different causes of thrombocytopenia in dogs in the United Kingdom and to investigate the utility of platelet concentration to differentiate causes of thrombocytopenia. Methods Medical records of 762 dogs with thrombocytopenia presented to seven referral hospitals from January 2017 to December 2018 were retrospectively reviewed. Cases were assigned into the following categories: pITP, infectious diseases, neoplasia, inflammatory/other immune‐mediated disorders and miscellaneous causes. The prevalence of the different categories was estimated, and platelet concentrations were compared. Receiver‐operating characteristic (ROC) curves were used to investigate the utility of platelet concentration to differentiate between causes of thrombocytopenia. Results The most common disease category associated with thrombocytopenia was neoplasia (27.3%), followed by miscellaneous causes (26.9%), pITP (18.8%), inflammatory/immune‐mediated disorders (14.4%) and infectious diseases (12.6%). Dogs with pITP had significantly lower platelet concentrations (median 8 × 109/L, range: 0–70 × 109/L) than dogs in the other four categories. Platelet concentration was useful for distinguishing pITP from other causes of thrombocytopenia (area under ROC curve = 0.89, 95% confidence interval 0.87, 0.92), with a platelet concentration ≤12 × 109/L being 60% sensitive and 90% specific. Conclusions Severe thrombocytopenia was highly specific for a diagnosis of pITP, which was more prevalent in this UK population of thrombocytopenic dogs compared with previous epidemiological studies. Conversely, the proportion of dogs with infectious diseases was lower than in previous reports from other locations.https://doi.org/10.1002/vms3.1091canineplateletsprevalencethrombocytopeniaUnited Kingdom |
| spellingShingle | Marina Martín‐Ambrosio Francés Mayank Seth Mellora Sharman Danica Pollard Ana Liza Ortiz Rachel Miller Thomas Natsiopoulos David Walker Bryn Jones Joshua Hardwick Barbara Glanemann Andrés Salas Garcia Jessica Bacon Aida Gómez Selgas Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases Veterinary Medicine and Science canine platelets prevalence thrombocytopenia United Kingdom |
| title | Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases |
| title_full | Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases |
| title_fullStr | Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases |
| title_full_unstemmed | Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases |
| title_short | Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases |
| title_sort | causes of thrombocytopenia in dogs in the united kingdom a retrospective study of 762 cases |
| topic | canine platelets prevalence thrombocytopenia United Kingdom |
| url | https://doi.org/10.1002/vms3.1091 |
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