TERT and TET2 Genetic Variants Affect Leukocyte Telomere Length and Clinical Outcome in Coronary Artery Disease Patients—A Possible Link to Clonal Hematopoiesis

TERT and TET2 Genetic Variants Affect Leukocyte Telomere Length and Clinical Outcome in Coronary Artery Disease Patients—A Possible Link to Clonal Hematopoiesis

Inherited and acquired mutations in hematopoietic stem cells can cause clonal expansion with increased risk of cardiovascular disease (CVD), a condition known for the clonal hematopoiesis of indeterminate potential (CHIP). Inherited genetic variants in two CHIP-associated genome loci, the telomerase...

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Bibliographic Details
Main Authors: Trine B. Opstad, Svein Solheim, Alf-Åge R. Pettersen, Are A. Kalstad, Harald Arnesen, Ingebjørg Seljeflot
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
TERT
TET2
telomere
genetic variation
clonal hematopoiesis
Online Access:https://www.mdpi.com/2227-9059/10/8/2027

Internet

https://www.mdpi.com/2227-9059/10/8/2027

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