UJI AKTIVITAS ANTIBAKTERI KRIM ASAM LAURAT TERHADAP Staphylococcus aureus ATCC 25923 DAN Pseudomonas aeruginosa ATCC 27853
Lauric acid is a saturated fatty acid found in fatty/vegetable oils, especially in palm oil. Lauric acid was reported to posses antiviral and antibacterial property. This study aims to determine the effect of the concentration variance of lauric acid in cream on the stability of the cream physical q...
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| Format: | Article |
| Language: | English |
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Universitas Tadulako
2016-10-01
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| Series: | Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) |
| Subjects: | |
| Online Access: | http://jurnal.untad.ac.id/jurnal/index.php/Galenika/article/view/5955 |
| _version_ | 1819105140440825856 |
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| author | Evi Sulastri Mappiratu Mappiratu Annisa Kartika Sari |
| author_facet | Evi Sulastri Mappiratu Mappiratu Annisa Kartika Sari |
| author_sort | Evi Sulastri |
| collection | DOAJ |
| description | Lauric acid is a saturated fatty acid found in fatty/vegetable oils, especially in palm oil. Lauric acid was reported to posses antiviral and antibacterial property. This study aims to determine the effect of the concentration variance of lauric acid in cream on the stability of the cream physical quality and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. In this research, lauric acid concentration in cream was varied in 10%, 20%, and 30% and then tested for antibacterial activity using hole plate technique. The results of the evaluation of lauric acid cream preparation of Formula 1, Formula 2 and Formula 3 showed that the organoleptic and homogeneity tests of all formula was no difference during storage time, but the result of pH, viscosity, and dispersive power of all formula has difference during storage time (28 days). The antibacterial test results showed that the highest inhibition diameter was found in the use of lauric acid concentration of 30% for S.aureus (21.589 mm ± 0.18) and P.aeruginosa (14.25 ± 0.37 mm). Based on statistical analysis of the cream produced from the three concentrations of lauric acid, they were not stable because there are significant differences in pH, viscosity, and dispersive power during storage time (28 days). Keywords: lauric acid, antibacterial cream, Staphylococcus aureus, Pseudomonas aeruginosa. |
| first_indexed | 2024-12-22T02:17:31Z |
| format | Article |
| id | doaj.art-1f63270eee964b38b0d022f9b3c725c6 |
| institution | Directory Open Access Journal |
| issn | 2442-7284 2442-8744 |
| language | English |
| last_indexed | 2024-12-22T02:17:31Z |
| publishDate | 2016-10-01 |
| publisher | Universitas Tadulako |
| record_format | Article |
| series | Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) |
| spelling | doaj.art-1f63270eee964b38b0d022f9b3c725c62022-12-21T18:42:14ZengUniversitas TadulakoJurnal Farmasi Galenika (Galenika Journal of Pharmacy)2442-72842442-87442016-10-0122596710.22487/j24428744.2016.v2.i2.59554766UJI AKTIVITAS ANTIBAKTERI KRIM ASAM LAURAT TERHADAP Staphylococcus aureus ATCC 25923 DAN Pseudomonas aeruginosa ATCC 27853Evi Sulastri0Mappiratu Mappiratu1Annisa Kartika Sari2Universitas TadulakoUniversitas TadulakoUniversitas TadulakoLauric acid is a saturated fatty acid found in fatty/vegetable oils, especially in palm oil. Lauric acid was reported to posses antiviral and antibacterial property. This study aims to determine the effect of the concentration variance of lauric acid in cream on the stability of the cream physical quality and antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa. In this research, lauric acid concentration in cream was varied in 10%, 20%, and 30% and then tested for antibacterial activity using hole plate technique. The results of the evaluation of lauric acid cream preparation of Formula 1, Formula 2 and Formula 3 showed that the organoleptic and homogeneity tests of all formula was no difference during storage time, but the result of pH, viscosity, and dispersive power of all formula has difference during storage time (28 days). The antibacterial test results showed that the highest inhibition diameter was found in the use of lauric acid concentration of 30% for S.aureus (21.589 mm ± 0.18) and P.aeruginosa (14.25 ± 0.37 mm). Based on statistical analysis of the cream produced from the three concentrations of lauric acid, they were not stable because there are significant differences in pH, viscosity, and dispersive power during storage time (28 days). Keywords: lauric acid, antibacterial cream, Staphylococcus aureus, Pseudomonas aeruginosa.http://jurnal.untad.ac.id/jurnal/index.php/Galenika/article/view/5955lauric acidantibacterial creamStaphylococcus aureusPseudomonas aeruginosa |
| spellingShingle | Evi Sulastri Mappiratu Mappiratu Annisa Kartika Sari UJI AKTIVITAS ANTIBAKTERI KRIM ASAM LAURAT TERHADAP Staphylococcus aureus ATCC 25923 DAN Pseudomonas aeruginosa ATCC 27853 Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) lauric acid antibacterial cream Staphylococcus aureus Pseudomonas aeruginosa |
| title | UJI AKTIVITAS ANTIBAKTERI KRIM ASAM LAURAT TERHADAP Staphylococcus aureus ATCC 25923 DAN Pseudomonas aeruginosa ATCC 27853 |
| title_full | UJI AKTIVITAS ANTIBAKTERI KRIM ASAM LAURAT TERHADAP Staphylococcus aureus ATCC 25923 DAN Pseudomonas aeruginosa ATCC 27853 |
| title_fullStr | UJI AKTIVITAS ANTIBAKTERI KRIM ASAM LAURAT TERHADAP Staphylococcus aureus ATCC 25923 DAN Pseudomonas aeruginosa ATCC 27853 |
| title_full_unstemmed | UJI AKTIVITAS ANTIBAKTERI KRIM ASAM LAURAT TERHADAP Staphylococcus aureus ATCC 25923 DAN Pseudomonas aeruginosa ATCC 27853 |
| title_short | UJI AKTIVITAS ANTIBAKTERI KRIM ASAM LAURAT TERHADAP Staphylococcus aureus ATCC 25923 DAN Pseudomonas aeruginosa ATCC 27853 |
| title_sort | uji aktivitas antibakteri krim asam laurat terhadap staphylococcus aureus atcc 25923 dan pseudomonas aeruginosa atcc 27853 |
| topic | lauric acid antibacterial cream Staphylococcus aureus Pseudomonas aeruginosa |
| url | http://jurnal.untad.ac.id/jurnal/index.php/Galenika/article/view/5955 |
| work_keys_str_mv | AT evisulastri ujiaktivitasantibakterikrimasamlauratterhadapstaphylococcusaureusatcc25923danpseudomonasaeruginosaatcc27853 AT mappiratumappiratu ujiaktivitasantibakterikrimasamlauratterhadapstaphylococcusaureusatcc25923danpseudomonasaeruginosaatcc27853 AT annisakartikasari ujiaktivitasantibakterikrimasamlauratterhadapstaphylococcusaureusatcc25923danpseudomonasaeruginosaatcc27853 |