Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission

Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission

Mitochondrial dysfunction and oxidative stress are considered to be two main drivers of diabetic myocardial ischemia-reperfusion injury (DM + MIRI). Nuclear factor-erythroid 2-related factor 2 (Nrf2) and Dynamin-related protein 1 (Drp1) play central roles in maintaining mitochondrial homeostasis and...

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Bibliographic Details
Main Authors:	Wang Xiao-Li, Zhu Qian-Qian, Simayi Alimujiang, Xu Gui-Ping
Format:	Article
Language:	English
Published:	De Gruyter 2023-06-01
Series:	Open Medicine
Subjects:	diabetes mellitus myocardial ischemia-reperfusion injury nuclear factor e2-related factor 2 dynamin-related protein 1 dimethyl fumarate
Online Access:	https://doi.org/10.1515/med-2023-0711

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