Early Effects of Combretastatin-A4 Disodium Phosphate on Tumor Perfusion and Interstitial Fluid Pressure

Early Effects of Combretastatin-A4 Disodium Phosphate on Tumor Perfusion and Interstitial Fluid Pressure

Combretastatin-A4 disodium phosphate (CA4DP) is a vascular-disruptive agent that causes an abrupt decrease in tumor blood flow. The direct actions of CA4DP include increases in vascular permeability and destabilization of the endothelial cytoskeleton, which are thought to contribute to occlusion of...

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Bibliographic Details
Main Authors: Carsten D. Ley, Michael R. Horsman, Paul E.G. Kristjansen
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Combretastatin-A4 disodium phosphate
interstitial fluid pressure
perfusion
wick-in-needle
vascular-damaging agent
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800406

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