Four Cases of the Rare Skin Manifestation: Monoclonal-Proteinemia
The skin manifestations of monoclonal(M)-proteinemia are rare and present in patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering plasma cell myeloma (SMM) and multiple myeloma (MM). In this study, we reported 4 cases with M-proteinemia-related rare skin lesions, inclu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Rare Diseases
2022-10-01
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| Series: | 罕见病研究 |
| Subjects: | |
| Online Access: | https://jrd.chard.org.cn/article/doi/10.12376/j.issn.2097-0501.2022.04.013 |
| _version_ | 1797369852235612160 |
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| author | JIN Xianghong XU Junqing YANG Chen ZHU Tienan ZHUANG Junling |
| author_facet | JIN Xianghong XU Junqing YANG Chen ZHU Tienan ZHUANG Junling |
| author_sort | JIN Xianghong |
| collection | DOAJ |
| description | The skin manifestations of monoclonal(M)-proteinemia are rare and present in patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering plasma cell myeloma (SMM) and multiple myeloma (MM). In this study, we reported 4 cases with M-proteinemia-related rare skin lesions, including pyoderma gangrenosum (PG), erythema elevatum diutinum (EED), cutis laxa (CL) and lichen myxedematosus(LM). These skin lesions are specific, where the potential mechanism was immune-mediated paraneoplastic syndrome rather than direct plasma cell infiltration. Anti-plasma cell treatment was effective in treating skin lesions. The clinical outcome of MM-related skin changes was correlated to tumor control, whereas the prognosis of MGUS or SMM related skin lesions was favorable. Skin involvement in M-proteinemia is extremely rare and less well-known, which greatly impairs quality of life. The diagnosis and treatment of these 4 cases support the need for futher study. |
| first_indexed | 2024-03-08T17:52:52Z |
| format | Article |
| id | doaj.art-1f65ac378b5d49cfa18de0cd3c369fb1 |
| institution | Directory Open Access Journal |
| issn | 2097-0501 |
| language | zho |
| last_indexed | 2024-03-08T17:52:52Z |
| publishDate | 2022-10-01 |
| publisher | Editorial Office of Journal of Rare Diseases |
| record_format | Article |
| series | 罕见病研究 |
| spelling | doaj.art-1f65ac378b5d49cfa18de0cd3c369fb12024-01-02T06:36:28ZzhoEditorial Office of Journal of Rare Diseases罕见病研究2097-05012022-10-011444044510.12376/j.issn.2097-0501.2022.04.013Four Cases of the Rare Skin Manifestation: Monoclonal-ProteinemiaJIN XianghongXU JunqingYANG Chen0ZHU Tienan1ZHUANG Junling2Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaThe skin manifestations of monoclonal(M)-proteinemia are rare and present in patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering plasma cell myeloma (SMM) and multiple myeloma (MM). In this study, we reported 4 cases with M-proteinemia-related rare skin lesions, including pyoderma gangrenosum (PG), erythema elevatum diutinum (EED), cutis laxa (CL) and lichen myxedematosus(LM). These skin lesions are specific, where the potential mechanism was immune-mediated paraneoplastic syndrome rather than direct plasma cell infiltration. Anti-plasma cell treatment was effective in treating skin lesions. The clinical outcome of MM-related skin changes was correlated to tumor control, whereas the prognosis of MGUS or SMM related skin lesions was favorable. Skin involvement in M-proteinemia is extremely rare and less well-known, which greatly impairs quality of life. The diagnosis and treatment of these 4 cases support the need for futher study.https://jrd.chard.org.cn/article/doi/10.12376/j.issn.2097-0501.2022.04.013m-proteinemiaskin manifestationspyoderma gangrenosumerythema elevatum diutinumcutis laxalichen myxedematosus |
| spellingShingle | JIN Xianghong XU Junqing YANG Chen ZHU Tienan ZHUANG Junling Four Cases of the Rare Skin Manifestation: Monoclonal-Proteinemia 罕见病研究 m-proteinemia skin manifestations pyoderma gangrenosum erythema elevatum diutinum cutis laxa lichen myxedematosus |
| title | Four Cases of the Rare Skin Manifestation: Monoclonal-Proteinemia |
| title_full | Four Cases of the Rare Skin Manifestation: Monoclonal-Proteinemia |
| title_fullStr | Four Cases of the Rare Skin Manifestation: Monoclonal-Proteinemia |
| title_full_unstemmed | Four Cases of the Rare Skin Manifestation: Monoclonal-Proteinemia |
| title_short | Four Cases of the Rare Skin Manifestation: Monoclonal-Proteinemia |
| title_sort | four cases of the rare skin manifestation monoclonal proteinemia |
| topic | m-proteinemia skin manifestations pyoderma gangrenosum erythema elevatum diutinum cutis laxa lichen myxedematosus |
| url | https://jrd.chard.org.cn/article/doi/10.12376/j.issn.2097-0501.2022.04.013 |
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