The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells
Memory B cells and antibody-secreting cells are the two prime effector B cell populations that drive infection- and vaccine-induced long-term antibody-mediated immunity. The antibody-mediated immunity mostly relies on the formation of specialized structures within secondary lymphoid organs, called g...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185597/full |
| _version_ | 1797397121369899008 |
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| author | Koushik Roy Mainak Chakraborty Ashok Kumar Asit Kumar Manna Asit Kumar Manna Neeladri Sekhar Roy |
| author_facet | Koushik Roy Mainak Chakraborty Ashok Kumar Asit Kumar Manna Asit Kumar Manna Neeladri Sekhar Roy |
| author_sort | Koushik Roy |
| collection | DOAJ |
| description | Memory B cells and antibody-secreting cells are the two prime effector B cell populations that drive infection- and vaccine-induced long-term antibody-mediated immunity. The antibody-mediated immunity mostly relies on the formation of specialized structures within secondary lymphoid organs, called germinal centers (GCs), that facilitate the interactions between B cells, T cells, and antigen-presenting cells. Antigen-activated B cells may proliferate and differentiate into GC-independent plasmablasts and memory B cells or differentiate into GC B cells. The GC B cells undergo proliferation coupled to somatic hypermutation of their immunoglobulin genes for antibody affinity maturation. Subsequently, affinity mature GC B cells differentiate into GC-dependent plasma cells and memory B cells. Here, we review how the NFκB signaling system controls B cell proliferation and the generation of GC B cells, plasmablasts/plasma cells, and memory B cells. We also identify and discuss some important unanswered questions in this connection. |
| first_indexed | 2024-03-09T01:05:26Z |
| format | Article |
| id | doaj.art-1f67a90f42394efd923d272fab5cc708 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-09T01:05:26Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-1f67a90f42394efd923d272fab5cc7082023-12-11T10:03:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.11855971185597The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cellsKoushik Roy0Mainak Chakraborty1Ashok Kumar2Asit Kumar Manna3Asit Kumar Manna4Neeladri Sekhar Roy5Division of Microbiology and Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT, United StatesDivision of Immunology, Indian Council of Medical Research-National Institute of Cholera and Enteric Diseases, Kolkata, IndiaDivision of Microbiology and Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT, United StatesDivision of Microbiology and Immunology, Department of Pathology, School of Medicine, University of Utah, Salt Lake City, UT, United StatesHuntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, United StatesDepartment of Biochemistry, School of Medicine, Emory University, Atlanta, GA, United StatesMemory B cells and antibody-secreting cells are the two prime effector B cell populations that drive infection- and vaccine-induced long-term antibody-mediated immunity. The antibody-mediated immunity mostly relies on the formation of specialized structures within secondary lymphoid organs, called germinal centers (GCs), that facilitate the interactions between B cells, T cells, and antigen-presenting cells. Antigen-activated B cells may proliferate and differentiate into GC-independent plasmablasts and memory B cells or differentiate into GC B cells. The GC B cells undergo proliferation coupled to somatic hypermutation of their immunoglobulin genes for antibody affinity maturation. Subsequently, affinity mature GC B cells differentiate into GC-dependent plasma cells and memory B cells. Here, we review how the NFκB signaling system controls B cell proliferation and the generation of GC B cells, plasmablasts/plasma cells, and memory B cells. We also identify and discuss some important unanswered questions in this connection.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185597/fullB cellmemory B cellplasma cellNFκBand cell signaling |
| spellingShingle | Koushik Roy Mainak Chakraborty Ashok Kumar Asit Kumar Manna Asit Kumar Manna Neeladri Sekhar Roy The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells Frontiers in Immunology B cell memory B cell plasma cell NFκB and cell signaling |
| title | The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells |
| title_full | The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells |
| title_fullStr | The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells |
| title_full_unstemmed | The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells |
| title_short | The NFκB signaling system in the generation of B-cell subsets: from germinal center B cells to memory B cells and plasma cells |
| title_sort | nfκb signaling system in the generation of b cell subsets from germinal center b cells to memory b cells and plasma cells |
| topic | B cell memory B cell plasma cell NFκB and cell signaling |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185597/full |
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