A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy
Abstract Objective Post‐traumatic epilepsy (PTE) is an acquired epilepsy that develops in the months or years following a traumatic brain injury (TBI) and can lead to substantial personal, financial, and societal burden. To date, PTE is rarely curable; current treatments are partially effective and...
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Epilepsia Open |
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| Online Access: | https://doi.org/10.1002/epi4.12745 |
| _version_ | 1797729149502095360 |
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| author | Sloka S. Iyengar Laura S. Lubbers Lauren Harte‐Hargrove CURE Epilepsy Post‐Traumatic Initiative Advisors, and Investigators |
| author_facet | Sloka S. Iyengar Laura S. Lubbers Lauren Harte‐Hargrove CURE Epilepsy Post‐Traumatic Initiative Advisors, and Investigators |
| author_sort | Sloka S. Iyengar |
| collection | DOAJ |
| description | Abstract Objective Post‐traumatic epilepsy (PTE) is an acquired epilepsy that develops in the months or years following a traumatic brain injury (TBI) and can lead to substantial personal, financial, and societal burden. To date, PTE is rarely curable; current treatments are partially effective and often accompanied by adverse side effects. While research on PTE has expanded significantly in the last several years, there remain numerous challenges to identifying effective prevention and treatment strategies. In this paper, we describe advances from the CURE Epilepsy PTE Initiative, including its implementation and the emphasis on team science. Methods The CURE Epilepsy PTE Initiative funded six research teams to link preclinical and clinical studies to engage in the validation of experimental models, characterization of pathophysiology and biological pathways, and identification of risk factors associated with PTE. Three teams had projects with both a preclinical and a clinical component; these teams focused on: targeting the epileptogenic effects of subarachnoid blood, exploring the neuropathological mechanisms of epileptogenesis, and defining the role of extracellular matrix injury. Two teams undertook entirely preclinical projects: exploring the role of vascular injury, gliosis, and neurogenesis as drivers for PTE, and identifying genetic, proteomic, metabolomic, and microRNA biosignatures to improve the prediction of PTE. One team's project was entirely clinical and investigated genetic and protein biomarkers to improve the prediction of PTE. Results In addition to scientific discoveries including characterization of a variety of animal models and progress towards the understanding of biological underpinnings and biomarkers for PTE, significant programmatic and personnel‐related processes were incorporated, including standardized, rigorous policies and procedures to ensure quality and accountability between and within groups. Significance We propose CURE Epilepsy's team science approach as an effective way to bring together a diverse set of investigators to explore biological mechanisms that may lead to cures for the epilepsies. |
| first_indexed | 2024-03-12T11:24:52Z |
| format | Article |
| id | doaj.art-1f68d7e476554ced9636772f3badff14 |
| institution | Directory Open Access Journal |
| issn | 2470-9239 |
| language | English |
| last_indexed | 2024-03-12T11:24:52Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Epilepsia Open |
| spelling | doaj.art-1f68d7e476554ced9636772f3badff142023-09-01T09:39:50ZengWileyEpilepsia Open2470-92392023-09-018382083310.1002/epi4.12745A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsySloka S. Iyengar0Laura S. Lubbers1Lauren Harte‐Hargrove2CURE Epilepsy Post‐Traumatic Initiative Advisors, and InvestigatorsCURE Epilepsy Chicago Illinois USACURE Epilepsy Chicago Illinois USACURE Epilepsy Chicago Illinois USAAbstract Objective Post‐traumatic epilepsy (PTE) is an acquired epilepsy that develops in the months or years following a traumatic brain injury (TBI) and can lead to substantial personal, financial, and societal burden. To date, PTE is rarely curable; current treatments are partially effective and often accompanied by adverse side effects. While research on PTE has expanded significantly in the last several years, there remain numerous challenges to identifying effective prevention and treatment strategies. In this paper, we describe advances from the CURE Epilepsy PTE Initiative, including its implementation and the emphasis on team science. Methods The CURE Epilepsy PTE Initiative funded six research teams to link preclinical and clinical studies to engage in the validation of experimental models, characterization of pathophysiology and biological pathways, and identification of risk factors associated with PTE. Three teams had projects with both a preclinical and a clinical component; these teams focused on: targeting the epileptogenic effects of subarachnoid blood, exploring the neuropathological mechanisms of epileptogenesis, and defining the role of extracellular matrix injury. Two teams undertook entirely preclinical projects: exploring the role of vascular injury, gliosis, and neurogenesis as drivers for PTE, and identifying genetic, proteomic, metabolomic, and microRNA biosignatures to improve the prediction of PTE. One team's project was entirely clinical and investigated genetic and protein biomarkers to improve the prediction of PTE. Results In addition to scientific discoveries including characterization of a variety of animal models and progress towards the understanding of biological underpinnings and biomarkers for PTE, significant programmatic and personnel‐related processes were incorporated, including standardized, rigorous policies and procedures to ensure quality and accountability between and within groups. Significance We propose CURE Epilepsy's team science approach as an effective way to bring together a diverse set of investigators to explore biological mechanisms that may lead to cures for the epilepsies.https://doi.org/10.1002/epi4.12745CURE Epilepsypost‐traumatic epilepsy (PTE)seizuresteam Sciencetraumatic brain injury (TBI) |
| spellingShingle | Sloka S. Iyengar Laura S. Lubbers Lauren Harte‐Hargrove CURE Epilepsy Post‐Traumatic Initiative Advisors, and Investigators A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy Epilepsia Open CURE Epilepsy post‐traumatic epilepsy (PTE) seizures team Science traumatic brain injury (TBI) |
| title | A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy |
| title_full | A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy |
| title_fullStr | A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy |
| title_full_unstemmed | A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy |
| title_short | A team science approach for the preclinical and clinical characterization and biomarker development for post‐traumatic epilepsy |
| title_sort | team science approach for the preclinical and clinical characterization and biomarker development for post traumatic epilepsy |
| topic | CURE Epilepsy post‐traumatic epilepsy (PTE) seizures team Science traumatic brain injury (TBI) |
| url | https://doi.org/10.1002/epi4.12745 |
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