Influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusion
Abstract Background Even undergoing mechanical thrombectomy (MT), patients with acute vertebrobasilar artery occlusion (AVBAO) still have a high rate of mortality. Tirofiban is a novel antiplatelet agent which is now widely empirically used in acute ischemic stroke (AIS). In this study, we aimed to...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-022-02996-5 |
| _version_ | 1811188918808215552 |
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| author | Xiding Pan Mengyi Xu Yuxiang Fei Shiteng Lin Yapeng Lin Jianjun Zou Jie Yang |
| author_facet | Xiding Pan Mengyi Xu Yuxiang Fei Shiteng Lin Yapeng Lin Jianjun Zou Jie Yang |
| author_sort | Xiding Pan |
| collection | DOAJ |
| description | Abstract Background Even undergoing mechanical thrombectomy (MT), patients with acute vertebrobasilar artery occlusion (AVBAO) still have a high rate of mortality. Tirofiban is a novel antiplatelet agent which is now widely empirically used in acute ischemic stroke (AIS). In this study, we aimed to evaluate the safety and efficacy of tirofiban as adjunctive therapy for MT in AVBAO. Methods From October 2016 to July 2021, consecutive AVBAO patients receiving MT were included in the prospective stroke registry. The short-term outcomes were (1) symptomatic intracerebral hemorrhage (sICH); (2) in-hospital death; (3) National Institute of Health Stroke Scale (NIHSS) at discharge. The Long-term outcomes were: (1) modified Rankin Scale (mRS) at 3 months; (2) death at 3 months. Results A total of 130 eligible patients were included in the study, 64 (49.2%) patients received tirofiban. In multivariate regression analysis, no significant differences were observed in all outcomes between the tirofiban and non-tirofiban group [sICH (adjusted OR 0.96; 95% CI, 0.12–7.82, p = 0.97), in-hospital death (adjusted OR 0.57; 95% CI, 0.17–1.89, p = 0.36), NIHSS at discharge (95% CI, -2.14–8.63, p = 0.24), mRS (adjusted OR 1.20; 95% CI, 0.40–3.62, p = 0.75), and death at 3 months (adjusted OR 0.83; 95% CI, 0.24–2.90, p = 0.77)]. Conclusions In AVBAO, tirofiban adjunctive to MT was not associated with an increased risk of sICH. Short-term (in-hospital death, NIHSS at discharge) and long-term outcomes (mRS and death at 3 months) seem not to be influenced by tirofiban use. |
| first_indexed | 2024-04-11T14:27:29Z |
| format | Article |
| id | doaj.art-1f6a631da66447799a6d3b0e29d2c6c8 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-11T14:27:29Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-1f6a631da66447799a6d3b0e29d2c6c82022-12-22T04:18:48ZengBMCBMC Neurology1471-23772022-12-012211610.1186/s12883-022-02996-5Influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusionXiding Pan0Mengyi Xu1Yuxiang Fei2Shiteng Lin3Yapeng Lin4Jianjun Zou5Jie Yang6Department of Pharmacy, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Neurology, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Pharmacy, Nanjing First Hospital, Nanjing Medical UniversitySchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical UniversityInternational Clinical Research Center & Department of Neurology, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeDepartment of Pharmacy, Nanjing First Hospital, Nanjing Medical UniversityInternational Clinical Research Center & Department of Neurology, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical CollegeAbstract Background Even undergoing mechanical thrombectomy (MT), patients with acute vertebrobasilar artery occlusion (AVBAO) still have a high rate of mortality. Tirofiban is a novel antiplatelet agent which is now widely empirically used in acute ischemic stroke (AIS). In this study, we aimed to evaluate the safety and efficacy of tirofiban as adjunctive therapy for MT in AVBAO. Methods From October 2016 to July 2021, consecutive AVBAO patients receiving MT were included in the prospective stroke registry. The short-term outcomes were (1) symptomatic intracerebral hemorrhage (sICH); (2) in-hospital death; (3) National Institute of Health Stroke Scale (NIHSS) at discharge. The Long-term outcomes were: (1) modified Rankin Scale (mRS) at 3 months; (2) death at 3 months. Results A total of 130 eligible patients were included in the study, 64 (49.2%) patients received tirofiban. In multivariate regression analysis, no significant differences were observed in all outcomes between the tirofiban and non-tirofiban group [sICH (adjusted OR 0.96; 95% CI, 0.12–7.82, p = 0.97), in-hospital death (adjusted OR 0.57; 95% CI, 0.17–1.89, p = 0.36), NIHSS at discharge (95% CI, -2.14–8.63, p = 0.24), mRS (adjusted OR 1.20; 95% CI, 0.40–3.62, p = 0.75), and death at 3 months (adjusted OR 0.83; 95% CI, 0.24–2.90, p = 0.77)]. Conclusions In AVBAO, tirofiban adjunctive to MT was not associated with an increased risk of sICH. Short-term (in-hospital death, NIHSS at discharge) and long-term outcomes (mRS and death at 3 months) seem not to be influenced by tirofiban use.https://doi.org/10.1186/s12883-022-02996-5Vertebrobasilar artery occlusionAntiplateletTirofibanMechanical thrombectomy |
| spellingShingle | Xiding Pan Mengyi Xu Yuxiang Fei Shiteng Lin Yapeng Lin Jianjun Zou Jie Yang Influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusion BMC Neurology Vertebrobasilar artery occlusion Antiplatelet Tirofiban Mechanical thrombectomy |
| title | Influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusion |
| title_full | Influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusion |
| title_fullStr | Influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusion |
| title_full_unstemmed | Influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusion |
| title_short | Influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusion |
| title_sort | influence of tirofiban on stroke outcome after mechanical thrombectomy in acute vertebrobasilar artery occlusion |
| topic | Vertebrobasilar artery occlusion Antiplatelet Tirofiban Mechanical thrombectomy |
| url | https://doi.org/10.1186/s12883-022-02996-5 |
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