Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease
Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-de...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00860/full |
| _version_ | 1818268528084516864 |
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| author | Paulina Troncoso-Escudero Paulina Troncoso-Escudero Paulina Troncoso-Escudero Paulina Troncoso-Escudero Alejandra Parra Alejandra Parra Alejandra Parra Alejandra Parra Melissa Nassif Rene L. Vidal Rene L. Vidal Rene L. Vidal Rene L. Vidal |
| author_facet | Paulina Troncoso-Escudero Paulina Troncoso-Escudero Paulina Troncoso-Escudero Paulina Troncoso-Escudero Alejandra Parra Alejandra Parra Alejandra Parra Alejandra Parra Melissa Nassif Rene L. Vidal Rene L. Vidal Rene L. Vidal Rene L. Vidal |
| author_sort | Paulina Troncoso-Escudero |
| collection | DOAJ |
| description | Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-derived immune cells. Furthermore, the evidence of the contribution of systemic delivered molecules to the disease pathogenesis, such as the gut microbiota composition, has been increasing during the last years. Under physiological conditions, microglia and astrocytes support the well-being and well-function of the brain through diverse functions, including neurotrophic factor secretion in both intact and injured brain. On the other hand, genes that cause PD are expressed in astrocytes and microglia, shifting their neuroprotective role to a pathogenic one, contributing to disease onset and progression. In addition, growth factors are a subset of molecules that promote cellular survival, differentiation and maturation, which are critical signaling factors promoting the communication between cells, including neurons and blood-derived immune cells. We summarize the potential targeting of astrocytes and microglia and the systemic contribution of the gut microbiota in neuroinflammation process archived in PD. |
| first_indexed | 2024-12-12T20:39:55Z |
| format | Article |
| id | doaj.art-1f6a71ed4425476e85b9c757d0064a43 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-12T20:39:55Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-1f6a71ed4425476e85b9c757d0064a432022-12-22T00:12:46ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-10-01910.3389/fneur.2018.00860413854Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's DiseasePaulina Troncoso-Escudero0Paulina Troncoso-Escudero1Paulina Troncoso-Escudero2Paulina Troncoso-Escudero3Alejandra Parra4Alejandra Parra5Alejandra Parra6Alejandra Parra7Melissa Nassif8Rene L. Vidal9Rene L. Vidal10Rene L. Vidal11Rene L. Vidal12Faculty of Sciences, Center for Integrative Biology, Universidad Mayor, Santiago, ChileBiomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, ChileProgram of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, ChileGeroscience Center for Brain Health and Metabolism (GERO), Santiago, ChileFaculty of Sciences, Center for Integrative Biology, Universidad Mayor, Santiago, ChileBiomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, ChileProgram of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, ChileGeroscience Center for Brain Health and Metabolism (GERO), Santiago, ChileFaculty of Sciences, Center for Integrative Biology, Universidad Mayor, Santiago, ChileFaculty of Sciences, Center for Integrative Biology, Universidad Mayor, Santiago, ChileBiomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, ChileGeroscience Center for Brain Health and Metabolism (GERO), Santiago, ChileNeurounion Biomedical Foundation, Santiago, ChileNeuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules released from brain-resident and/or blood-derived immune cells. Furthermore, the evidence of the contribution of systemic delivered molecules to the disease pathogenesis, such as the gut microbiota composition, has been increasing during the last years. Under physiological conditions, microglia and astrocytes support the well-being and well-function of the brain through diverse functions, including neurotrophic factor secretion in both intact and injured brain. On the other hand, genes that cause PD are expressed in astrocytes and microglia, shifting their neuroprotective role to a pathogenic one, contributing to disease onset and progression. In addition, growth factors are a subset of molecules that promote cellular survival, differentiation and maturation, which are critical signaling factors promoting the communication between cells, including neurons and blood-derived immune cells. We summarize the potential targeting of astrocytes and microglia and the systemic contribution of the gut microbiota in neuroinflammation process archived in PD.https://www.frontiersin.org/article/10.3389/fneur.2018.00860/fullParkinson's diseaseneuroinflammationgut microbiotaneurotrophic factorneurodegenerative disease |
| spellingShingle | Paulina Troncoso-Escudero Paulina Troncoso-Escudero Paulina Troncoso-Escudero Paulina Troncoso-Escudero Alejandra Parra Alejandra Parra Alejandra Parra Alejandra Parra Melissa Nassif Rene L. Vidal Rene L. Vidal Rene L. Vidal Rene L. Vidal Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease Frontiers in Neurology Parkinson's disease neuroinflammation gut microbiota neurotrophic factor neurodegenerative disease |
| title | Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease |
| title_full | Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease |
| title_fullStr | Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease |
| title_full_unstemmed | Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease |
| title_short | Outside in: Unraveling the Role of Neuroinflammation in the Progression of Parkinson's Disease |
| title_sort | outside in unraveling the role of neuroinflammation in the progression of parkinson s disease |
| topic | Parkinson's disease neuroinflammation gut microbiota neurotrophic factor neurodegenerative disease |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00860/full |
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